Objective: To discuss the influence of the number of lymph nodes retrieved after selective neck dissection on the prognosis of hypopharyngeal squamous carcinoma.
Methods: A retrospective review was performed on 96 patients with hypopharyngeal squamous carcinoma between January 1995 and December 2009, and all cases were accepted initial treatment for selective neck dissection. t test was used for analysis of normally distributed and Mann-Whitney U test for non-normally distributed continuous data in two groups. Comparisons were made by χ(2) analysis for categorical variables. Overall survival, disease-free survival and neck-control rate were calculated by the Kaplan-Meier method.
Results: The mean number of lymph nodes retrieved in all patients with hypopharyngeal squamous carcinoma was 19.0 ± 11.3. Preoperative radiotherapy significantly decreased the number of retrieved lymph nodes and positive lymph nodes (t = -4.45, P < 0.001 and U = 568, P < 0.001, respectively). The number of nodes retrieved ≤ 15 was associated with 3-year overall survival of 37.7% compared with 71.3% in those with nodes retrieved > 15 by using Kaplan-Meier analysis (χ(2) = 8.214, P < 0.01). 3-year disease-free survival rates were 34.8% in those with ≤ 15 nodes and 61.7% in patients with > 15 nodes (χ(2) = 7.345, P < 0.01). The 3-year neck-control rates were 97.4% and 76.7% (> 15 nodes vs. ≤ 15 nodes;χ(2) = 5.539, P < 0.05), respectively. After adjusting for the effect of T stage and N stage on multivariate analysis, the number of nodes retrieved > 15 was an independent prognostic factor in patients undergoing selective neck dissection for hypopharyngeal squamous carcinoma (P < 0.05).
Conclusions: The number of lymph nodes retrieved is a valuable prognostic factor in patients received selective neck dissection for hypopharyngeal squamous carcinoma. These results suggest that at least 15 nodes should be examined in this setting.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Head and neck automatic multi-organ segmentation on Dual-Energy Computed Tomography.
Phys Imaging Radiat Oncol
October 2024
Université Paris-Saclay, Gustave Roussy, Inserm, Molecular Radiotherapy and Therapeutic Innovation, U1030, 94800 Villejuif, France.
Background And Purpose: Deep-learning-based automatic segmentation is widely used in radiation oncology to delineate organs-at-risk. Dual-energy CT (DECT) allows the reconstruction of enhanced contrast images that could help with manual and auto-delineation. This paper presents a performance evaluation of a commercial auto-segmentation software on image series generated by a DECT.
View Article and Find Full Text PDFSequence of Chemotherapy May Not Impact Survival After Resection of Pancreatic Tail Adenocarcinoma.
J Surg Oncol
January 2025
Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK.
Introduction: Pancreatic ductal adenocarcinoma (PDAC) of the body/tail is notably different than PDAC in the head of the pancreas. Surgery plus chemotherapy is known to improve outcomes for all PDAC. The sequence of this therapy is well studied in head cancers yet has never been evaluated systematically in relation to distal pancreatectomy (DP).
View Article and Find Full Text PDFThe prognostic value of changes in Ki67 following neoadjuvant chemotherapy in residual triple-negative breast cancer: a Swedish nationwide registry-based study.
Breast Cancer Res Treat
January 2025
Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Article Synopsis
- The study investigates how changes in the Ki67 biomarker before and after neoadjuvant chemotherapy (NACT) affect survival in patients with triple-negative breast cancer (TNBC).
- Among 1,777 TNBC patients analyzed, most showed a decrease in tumor size and Ki67 levels after NACT, though many had no change or experienced treatment discontinuation.
- Patients with unchanged Ki67 had significantly worse overall and disease-specific survival compared to those with decreased Ki67, emphasizing the need for personalized treatment strategies based on ongoing monitoring of this biomarker.
Progressive Bounded Error Piecewise Linear Approximation with Resolution Reduction for Time Series Data Compression.
Sensors (Basel)
December 2024
Department of Information Management, Tunghai University, Taichung 407224, Taiwan.
Today, huge amounts of time series data are sensed continuously by AIoT devices, transmitted to edge nodes, and to data centers. It costs a lot of energy to transmit these data, store them, and process them. Data compression technologies are commonly used to reduce the data size and thus save energy.
View Article and Find Full Text PDFPrognostic significance of three lymph node staging systems in pancreatic cancer with ≤ 12 and > 12 retrieved lymph nodes.
Updates Surg
January 2025
Department of General Surgery, Department of Hepato-Bilio-Pancreatic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Da Hua Road, Dong Dan, Beijing, 100730, People's Republic of China.
Article Synopsis
- The study compared the predictive effectiveness of negative lymph nodes (NLN), lymph node ratio (LNR), and N stage in pancreatic ductal adenocarcinoma (PDAC) patients based on the number of retrieved lymph nodes.
- All three nodal staging systems were found to independently predict cancer-specific survival (CSS) and overall survival (OS), with improved survival linked to higher NLN, lower LNR, and lower N stage.
- LNR outperformed N stage in predicting prognosis, while NLN had limited effectiveness, particularly in predicting survival for patients with stage N0 disease.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!