Paul Soloway's development of single molecule approaches to study epigenetics caught our attention. Curious to know more, BioTechniques contacted him to find out about the ambition, character, and motivation that led to his success.
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A Malleable Collagen-Mimic that Undergoes Moisture-Induced Hardening for Gluing Hydrophilic Surfaces.
Angew Chem Int Ed Engl
January 2025
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Bioceramics Division, Biomedical Technology Wing, 695011, Thiruvananthapuram, INDIA.
A collagen-inspired helical protein-mimic has been synthesized via topochemical polymerization of a designed tripeptide monomer. In the monomer crystal, molecules arrange in a head-to-tail manner, forming supramolecular helices. The azide and alkyne of adjacent molecules in the supramolecular helix are proximally preorganized in a ready-to-react arrangement.
View Article and Find Full Text PDFPyrazoline and Pyrazoline Derivatives as Anti-Cancer Agents: Synthesis and Biological Activities: A Compressive Review.
Curr Top Med Chem
January 2025
Department of Pharmacy, Harlal Institute of Management and Technology (HIMT), Plot no-8, knowledge park-1,Greater Noida, Uttar Pradesh -201310, India.
Background: A heterocyclic molecule containing five rings, three carbon atoms, two nitrogen atoms, and a single endocyclic bond is called pyrazoline. Because of its intriguing electrical characteristics and potential for dynamic applications, pyrazoline is one type of electron-rich nitrogen carrier that is becoming more and more popular. This study synthesizes pyrazoline derivatives using a variety of techniques to demonstrate a highly biological function.
View Article and Find Full Text PDFA Facile Approach to Tetracyclic Indolines: Highly Diastereoselective [4+2] Annulation of Indoles with Bicyclic N-Substituted Cyclobutanes.
J Org Chem
January 2025
Chang-Kung Chuang Institute, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, College of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
A new stereoselective [4+2] annulation method for constructing tetracyclic indolines by reacting indoles with bicyclic N-substituted cyclobutanes has been developed. Using Sc(OTf) as a catalyst, a series of tetracyclic indolines with four continued stereogenic carbon centers have been obtained in ≤86% yields as single diastereomers. This reaction offers an accessible way for the rapid construction of the core structures of biologically active natural products like paucidirinine, deethylibophyllidine, and ibophyllidine.
View Article and Find Full Text PDFExploring the diffusion of DNA strands into nanoporous structures for establishing a universal electrochemical biosensor.
Chem Sci
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School of Chemistry and Chemical Engineering, Shandong University Jinan 250100 China
The development of universal electrochemical sensing platforms with high sensitivity and specificity is of great significance for advancing practical disease diagnostic methods and devices. Exploring the structural properties of electrode materials and their interaction with biomolecules is essential to developing novel and distinctive analytical approaches. Here, we innovatively investigated the effect of DNA length and configuration on DNA molecule transfer into the nanostructure of a nanoporous gold (NPG) electrode.
View Article and Find Full Text PDFQuantitative fluorescent nanoparticle tracking analysis and nano-flow cytometry enable advanced characterization of single extracellular vesicles.
J Extracell Biol
January 2025
RoseBio Milano Italy.
Current state-of-the-art tools for analysing extracellular vesicles (EVs) offer either highly sensitive but unidimensional bulk measurements of EV components, or high-resolution multiparametric single-particle analyses which lack standardization and appropriate reference materials. This limits the accuracy of the assessment of marker abundance and overall marker distribution amongst individual EVs, and finally, the understanding of true EV heterogeneity. In this study, we aimed to define the standardized operating procedures and reference material for fluorescent characterization of EVs with two commonly used EV analytical platforms-nanoparticle tracking analysis (NTA) and nano-flow cytometry (nFCM).
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