AI Article Synopsis
- Multiple electrode aggregometry (MEA) is a method for assessing platelet function, and the study investigated the impact of pneumatic tube transport systems (PTS) on this measurement.
- Duplicate samples from 58 individuals were analyzed, with one sample transported via PTS and the other manually delivered to the lab, revealing that PTS samples had significantly reduced platelet activity, sometimes by up to 100%.
- The findings indicate that clinical decisions regarding platelet function should not rely on PTS-transported samples due to their potential inaccuracies compared to samples delivered by personnel.
Article Abstract
Multiple electrode aggregometry (MEA) is used to measure platelet function. Pneumatic tube transport systems (PTS) for delivery of patient samples to a central laboratory are often used to reduce turnaround time for vital analyses. We evaluated the effects of PTS transport on platelet function as measured by MEA. Duplicate samples were collected from 58 individuals. One sample was sent using PTS and the other was carried by personnel to the lab. Platelet function was measured by means of a Multiplate® analyzer using the ADP test, ASPI test, COL test, RISTO test and TRAP test. Samples transported using PTS showed a reduction of AUC-values of up to a 100% of the average as compared to samples carried by personnel and a majority showed reductions of AUC-values greater than 20% of the average. Bias±95% limits of agreement for the ADP test were 26±56% of the average. Bias±95% limits of agreement for the ASPI test were 16±58% of the average. Bias±95% limits of agreement for the COL test were 20±54% of the average. Bias±95% limits of agreement for the RISTO were 14±79% of the average. Bias±95% limits of agreement for the TRAP test were 19±45% of the average. We conclude that PTS transport affect platelet activity as measured by MEA. We advise against clinical decisions regarding platelet function on the basis of samples sent by PTS in our hospital settings.
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| http://dx.doi.org/10.1016/j.thromres.2013.04.020 | DOI Listing |
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