AI Article Synopsis
- The study aimed to investigate the differences in patient outcomes between those with systemic inflammatory response syndrome (SIRS) and those without, specifically in patients treated with intravenous tissue-type plasminogen activator (tPA).
- A total of 241 patients were analyzed, with 44 (18%) exhibiting SIRS, which was defined by certain clinical criteria, and patients with infections were excluded from the study.
- Results indicated that SIRS was linked to poorer functional outcomes at discharge and longer hospital stays, suggesting it is a significant factor in the recovery of tPA-treated patients.
Article Abstract
Background And Purpose: Systemic inflammatory response syndrome (SIRS) is a generalized inflammatory state. The primary goal of the study was to determine whether differences exist in outcomes in SIRS and non-SIRS intravenous tissue-type plasminogen activator-treated patients.
Methods: Consecutive patients were retrospectively reviewed for the evidence of SIRS during their admission. SIRS was defined as the presence of ≥2 of the following: body temperature<36°C or >38°C, heart rate>90, respiratory rate>20, and white blood cells<4000/mm or >12 000 mm, or >10% bands. Patients diagnosed with infection (via positive culture) were excluded.
Results: Of the 241 patients, 44 had evidence of SIRS (18%). Adjusting for pre-tissue-type plasminogen activator National Institutes of Health Stroke Scale, age, and race, SIRS remained a predictor of poor functional outcome at discharge (odds ratio [OR], 2.58; 95% confidence interval [CI], 1.16-5.73; P=0.0197).
Conclusions: In our sample of tissue-type plasminogen activator-treated (tPA) patients, ~1 in 5 patients developed SIRS. Furthermore, we found the presence of SIRS to be associated with poor short-term functional outcomes and prolonged length of stay.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786674 | PMC |
| http://dx.doi.org/10.1161/STROKEAHA.113.001371 | DOI Listing |
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