AI Article Synopsis
- Two new triterpenoids, schisphendilactone A and B, were discovered from the stems of Schisandra sphenanthera, alongside three known compounds.
- The structures of these compounds were analyzed using spectroscopic methods, with schisphendilactone A's configuration determined through single-crystal X-ray diffraction.
- Compound 2 showed moderate effectiveness against SW480 cancer cells, while compound 5 demonstrated strong anti-HIV-1 activity, with an EC50 of 0.52 μg/ml and a high therapeutic index of 117.12.
Article Abstract
Two new triterpenoids, schisphendilactone A and B (1 and 2), together with three known triterpenoids, were isolated from the stems of Schisandra sphenanthera. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 2 showed moderate inhibitory activity against SW480 cancer cell line, and compound 5 exhibited promising anti-HIV-1 activity with EC50 value of 0.52 μg ml(-1) and therapeutic index value of 117.12.
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| http://dx.doi.org/10.1007/s12272-013-0133-3 | DOI Listing |
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