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http://dx.doi.org/10.1136/acupmed-2013-010371 | DOI Listing |
The connectome describes the complete set of synaptic contacts through which neurons communicate. While the architecture of the $\textit{C. elegans}$ connectome has been extensively characterized, much less is known about the organization of causal signaling networks arising from functional interactions between neurons.
View Article and Find Full Text PDFLive human brain tissues provide unique opportunities for understanding the physiology and pathophysiology of synaptic transmission. Investigations have been limited to anatomy, electrophysiology, and protein localization-while crucial parameters such as synaptic vesicle dynamics were not visualized. Here we utilize zap-and-freeze time-resolved electron microscopy to overcome this hurdle.
View Article and Find Full Text PDFAnat Rec (Hoboken)
January 2025
Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Diet is one of a limited set of key ecological parameters defining primate species. A detailed understanding of dental functional correlates with primate diet is a key component for accurate dietary inference in fossil primates. Although considerable effort has been devoted to understanding post-canine dental function, incisor function remains poorly understood.
View Article and Find Full Text PDFMol Genet Genomic Med
January 2025
Department of Biology, Università Degli Studi Di Napoli "Federico II", Naples, Italy.
Background: The KHDC3L gene encodes a component of the subcortical maternal complex (SCMC). Biallelic mutations in this gene cause 5%-10% of biparental hydatidiform moles (BiHM), and a few maternal deletions in KHDC3L have been identified in women with recurrent pregnancy loss (RPL).
Method: In this study, we had a patient with a history of 10 pregnancy or neonatal losses, including spontaneous abortions, neonatal deaths, and molar pregnancy.
Clin Transl Med
January 2025
Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Background: Chromosomal instability (CIN), a hallmark of cancer, is commonly linked to poor prognosis in high-grade prostate cancer (PCa). Paradoxically, excessively high levels of CIN may impair cancer cell viability. Consequently, understanding how tumours adapt to CIN is critical for identifying novel therapeutic targets.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!