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Fibromuscular Dysplasia Clinical Phenotype Manifesting as a Distal Spontaneous Coronary Artery Dissection in a Middle-Aged Man.
Cureus
January 2025
Internal Medicine, University of Florida College of Medicine, Gainesville, USA.
Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease of medium-sized arteries that causes abnormal cellular growth in arterial walls and most commonly affects young to middle-aged women (20-50 years of age). While FMD often involves the renal arteries, it can affect any arterial bed. FMD has a characteristic angiographic appearance of a "string of beads.
View Article and Find Full Text PDFAssociation of Murray's law with atherosclerosis risk: Numerical validation of a general scaling law of arterial tree.
Comput Biol Med
January 2025
Department of Mechanical Engineering, Isfahan University of Technology, Isfahan, Iran. Electronic address:
Atherogenesis is prone in medium and large-sized vessels, such as the aorta and coronary arteries, where hemodynamic stress is critical. Low and oscillatory wall shear stress contributes significantly to endothelial dysfunction and inflammation. Murray's law minimizes energy expenditure in vascular networks and applies to small arteries.
View Article and Find Full Text PDFHypothermic machine perfusion in uterus transplantation in a porcine model: A proof of concept and the first results in graft preservation.
Acta Obstet Gynecol Scand
January 2025
Department of Gynecology, Rennes University Hospital, Hôpital Sud, Rennes, France.
Introduction: Graft optimization is a necessity in order to develop uterus transplantation from brain-dead donors, as a complement to living donors, as these grafts are rare and the last organs retrieved in multiple organ donation. The aim of this study was to assess the feasibility and interest of hypothermic machine perfusion (HMP) in uterus transplantation using a porcine model; secondary outcomes were the evaluation of the graft's tolerance to a prolonged cold ischaemia time and to find new biomarkers of uterus viability.
Material And Methods: Fifteen uterus allotransplantations were performed in a porcine model, after 18 h of cold ischaemia, divided in three groups: Static cold storage in a HTK solution, HMP (with the VitaSmart (™) machine Bridge to Life Ltd.
Recent Developments in Ventricular Assist Device Therapy.
Rev Cardiovasc Med
January 2025
Center for Preclinical Surgical & Interventional Research, The Texas Heart Institute, Houston, TX 77030, USA.
The evolution of left ventricular assist devices (LVADs) from large, pulsatile systems to compact, continuous-flow pumps has significantly improved implantation outcomes and patient mobility. Minimally invasive surgical techniques have emerged that offer reduced morbidity and enhanced recovery for LVAD recipients. Innovations in wireless power transfer technologies aim to mitigate driveline-related complications, enhancing patient safety and quality of life.
View Article and Find Full Text PDFMachine learning approach for noninvasive intracranial pressure estimation using pulsatile cranial expansion waveforms.
NPJ Digit Med
January 2025
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
Noninvasive methods for intracranial pressure (ICP) monitoring have emerged, but none has successfully replaced invasive techniques. This observational study developed and tested a machine learning (ML) model to estimate ICP using waveforms from a cranial extensometer device (brain4care [B4C] System). The model explored multiple waveform parameters to optimize mean ICP estimation.
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