Objective: To develop and validate a food frequency questionnaire (FFQ) to estimate the genistein intake in a Malaysian population of pregnant women.
Method: A single 24-h dietary recall was obtained from 40 male and female volunteers. A FFQ of commonly consumed genistein-rich foods was developed from these recalls, and a database of the genistein content of foods found in Malaysia was set up. The FFQ was validated against 7-d food diary (FD) kept by 46 pregnant women and against non-fasting serum samples obtained from 64 pregnant women. Reproducibility was assessed by comparing the responses on two FFQs administered approximately 1 month apart.
Results: The Pearson correlation coefficient between FFQ1 and FD was 0.724 and that between FFQ2 and FD was 0.807. Classification into the same or adjacent quintiles was 78% for FFQ1 versus FD and 88% for FFQ2 versus FD. A significant dose -- response relation was found between FFQ-estimated genistein intake and serum levels.
Conclusion: The FFQ developed is a reliable, valid tool for categorising people by level of genistein intake.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/09637486.2013.798269 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The phytoestrogen genistein improves hippocampal neurogenesis and cognitive impairment and decreases neuroinflammation in an animal model of metabolic syndrome.
J Neuroendocrinol
December 2024
Laboratory of Neuroendocrine Biochemistry, Instituto de Biología y Medicina Experimental, Buenos Aires, Argentina.
Metabolic syndrome (MS) is the medical term for the combination of at least three of the following factors: obesity, hyperlipidemia, hyperglycemia, insulin resistance, and hypertension. The spontaneously hypertensive rat (SHR) is an accepted animal model for the study of human MS that reveals all the features of the syndrome when fed high-fat, high-carbohydrate diets. The intake of high-fat diets in rats has been shown to produce brain neuropathology.
View Article and Find Full Text PDFPreventive and therapeutic effects of genistein and daidzein on anxiety-like behaviors in ovariectomized rats.
Neurosci Lett
January 2025
Faculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
Estrogen has demonstrated beneficial effects; however, it can also have unfavorable effects. Phytoestrogens are present in many consumable products and commonly used as supplements. These are of interest as they may have beneficial effects on mood with fewer undesirable effects on reproductive tissues.
View Article and Find Full Text PDFSalivary gland protective and antiinflammatory effects of genistein in Sjögren's syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha.
Cell Mol Biol Lett
December 2024
School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, 510140, China.
Article Synopsis
- - The study investigates how genistein can potentially treat Sjögren's syndrome (SS) by targeting the genistein-estrogen receptor alpha (ERα) complex, which regulates the X-inactive specific transcript (Xist) and impacts ferroptosis through acyl-CoA synthetase long-chain family member 4 (ACSL4) in salivary gland epithelial cells (SGECs).
- - Researchers used nondiabetic obese (NOD)/LtJ mice and treated SGECs with Interferon-γ to evaluate changes in symptoms like dry mouth and to examine pathological lesions and molecular mechanisms underlying SS.
- - Results showed that genistein reduced SS symptoms by increasing Xist expression and decreasing Acsl
Phthalate exposure and reproductive effects in rodents: a model for approaches on the protective role of natural products.
Reproduction
November 2024
L Barbisan, Structural and Functional Biology, UNESP, Botucatu, Brazil.
This review article summarizes the experimental findings in rodents published between 2014 and 2024 concerning phthalates exposure and reproductive outcomes. Rodents were chosen for this review since most studies that have developmental aspects in different phases of exposure and that address more in-depth reproductive mechanisms have been carried out in mice and rats. The evidence of adverse effects of phthalates on fetal development and human and animal reproduction is extensive, with impacts ranging from gene expression to physiological alterations.
View Article and Find Full Text PDFDietary Flavonoid Intake and Risk of Mild Cognitive Impairment in the Elderly: A Case-Control Study.
Nutr Metab Insights
October 2024
Department of Nutrition, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Background: This study investigates the association between dietary flavonoid intake and the incidence of mild cognitive impairment (MCI) through a matched case-control design.
Methods: Dietary intake was assessed using a food frequency questionnaire, comparing the intake of flavonoids between individuals with MCI and those with normal cognitive function. Logistic regression analysis was employed to evaluate the correlation between dietary flavonoid intake and the risk of MCI.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!