The Aim Of The Study: was to evaluate the influence of nuclear factor-kappaB inhibition on -SH groups concentration in liver of rat
Material And Methods: Experiments were performed on Wistar-Kyoto rats divided into following groups: group I (control) received saline; group II (ET-1) received endothelin 1 (12.5 microg/kg b.w.); Group III (BAY 11-7082) received a nuclear factor-kappaB (NF-kappaB) inhibitor (10 mg/kg b.w.); Group IV (BAY 11-7082+ET-1) received a nuclear factor-kappa B inhibitor (10 mg/kg b.w.) and 30 min later ET-1 (12.5 microg/kg b.w.).
Results: Administration of endothelin 1 (ET-1) at a dose 12.5 microg/kg b.w. resulted in a statistically significant decrease in the concentration of -SH groups (p < 0.05 vs control). In contrast, BAY11-7082 (10 mg/kg b.w.) significantly increased the level of -SH groups in the liver in ET-1 inquced oxidative stress (p < 0.02).
Conclusion: A nuclear factor-kappa B inhibitor (BAY 11-7082) at a dose 10 mg/kg b.w. showed a significant increase in the concentration of -SH groups in the liver, in ET-1 induced oxidative stress.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Outcomes of a transapical edge-to-edge repair system in secondary mitral regurgitation.
J Invasive Cardiol
January 2025
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University; NHC Key Laboratory of Ischemic Heart Diseases; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Objectives: The ValveClamp system (Hanyu Medical Technology) is a novel transcatheter edge-to-edge repair (TEER) system designed for ease of operation; however, there is a lack of data on its application in secondary mitral regurgitation (SMR). The authors report the mid-term outcomes of TEER using the ValveClamp system in SMR.
Methods: The study prospectively analyzed consecutive severe SMR patients who underwent transapical ValveClamp implantation at 10 Chinese centers.
Exploring the adoption of diaphragm and lung ultrasound (DLUS) by physiotherapists, physical therapists, and respiratory therapists: an updated scoping review.
Ultrasound J
January 2025
Physiotherapy Department, Blackpool Teaching Hospitals NHS Foundation Trust, Whinney Heys Road, Blackpool, FY3 8PY, UK.
Background: The adoption of diaphragm and lung ultrasound (DLUS) by physiotherapists, physical therapists, and respiratory therapists ("therapists") to examine and assess the diaphragm and lungs continues to grow. The aim of this updated scoping review is to re-explore and re-collate the evidence around the adoption of DLUS by therapists.
Methods: This scoping review followed the PRISMA-ScR guidelines.
Autonomous learning and creative cognition: the mediating effect of gifted students' self-efficacy.
Front Psychol
January 2025
Department of Educational Sciences, Aksaray Faculty of Education, Aksaray University, Aksaray, Türkiye.
Introduction: In today's world, it is of great importance to raise qualified learners whose creative thinking skills and self-efficacy are developed and who can make various choices and take responsibility for their choices as well as implementing them by making their own decisions. In this regard, the study examined the role of gifted students' self-efficacy (SE) as a mediator on the relationship between autonomous learning (AL) and creative cognition (CC).
Methods: A proposed conceptual model was tested using a cross-sectional survey design.
knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia.
Int J Ophthalmol
January 2025
Department of Encephalopathy, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430070, Hubei Province, China.
Aim: To explore the neuroprotective effects of high mobility group box 2 () knockdown on retinal ganglion cells (RGCs) in the retinal ischemia-reperfusion injury (RIRI).
Methods: Oxygen-glucose deprivation (OGD)-injured RGCs from postnatal three-day C57BL/6 mice pups and high intraocular pressure (IOP)-induced RIRI mice were used as cellular and animal models of RIRI. The expression of HMGB2 in the retina of RIRI mice and OGD-injured RGCs was detected through reverse transcription-polymerase chain reaction (RT-qPCR) and Western blotting.
m6A-modified lncRNA GAS5 promotes M1-polarization of microglia in alcohol use disorder.
Brain Res Bull
January 2025
Mental Health Center, the First Affiliated Hospital of Harbin Medical University, Heilongjiang, China. Electronic address:
Long noncoding RNA (lncRNA) are essential for modulating the onset and progression of alcohol use disorder (AUD). In this study, we investigated the molecular pathways through which lncRNA may contribute to AUD development. We assessed the expression levels of long noncoding RNA GAS5 (lncRNA GAS5) and microRNA-136-5p (miR-136-5p) in AUD tissue samples and cell lines using reverse transcription-quantitativepolymerase chain reaction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!