Interactions of transcriptions factors Nurr1, Pitx3, and EN1 are involved in the maturation and survival of adult midbrain dopaminergic neurons during a lifetime. The aim of the study was to evaluate the presence of mutations and single nucleotide polymorphisms in PITX3 gene in clinically diagnosed multisystem atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). In the group of 77 patients with MSA, 44 with PSP, and 6 with CBD, no pathogenic mutations were identified.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
pitx3 gene
8
multisystem atrophy
8
progressive supranuclear
8
supranuclear palsy
8
corticobasal degeneration
8
analysis pitx3
4
gene patients
4
patients multisystem
4
atrophy progressive
4
palsy corticobasal
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!