External hydrocephalus is believed to be benign but published cases do not clearly establish this prognosis. Five children with typical external hydrocephalus were given acetazolamide. Head circumference measurements or other investigations demonstrated therapeutic effectiveness in four of the five patients. Although this series is too small to establish that acetazolamide avoided external hydrocephalus-related adverse events, the drug's outstanding tolerance and anatomic effectiveness justify widespread use in all patients with CSF resorption disorders.
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