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[Recurrent amylase-producing multiple myeloma responding to pomalidomide and carfilzomib-containing therapies].
Rinsho Ketsueki
July 2019
Department of Hematology, Juntendo University School of Medicine.
A 73-year-old woman diagnosed with symptomatic multiple myeloma (MM; IgG-κ type, D&S: IIIA, ISS: 2) was administered bortezomib plus dexamethasone (BD) therapy. Post BD therapy, although autologous hematopoietic stem cell transplantation and thalidomide, lenalidomide, and melphalan/prednisolone/thalidomide (MPT) therapies were also performed, the patient remained unresponsive. However, the disease relapsed, and she eventually developed pantalgia.
View Article and Find Full Text PDFOverexpression of salivary-type amylase reduces the sensitivity to bortezomib in multiple myeloma cells.
Int J Hematol
November 2015
Division of Hematology, Department of Internal Medicine, Aichi Medical University, 1, 1 Karimata, Yazako, Nagakute, Aichi, 480-1195, Japan.
Amylase-producing myeloma exhibits refractoriness to chemotherapy and a dismal prognosis. In this study, we established a human myeloma cell line, 8226/AMY1, in which a lentivirally transfected AMY1 gene was stably expressed and explored its biological characteristics. 8226/AMY1 showed a survival advantage over mock control when treated with dexamethasone, bortezomib, and lenalidomide in vitro partly through inhibition of apoptosis induced by these reagents.
View Article and Find Full Text PDFA case of salivary-type amylase-producing multiple myeloma presenting as mediastinal plasmacytoma and myelomatous pleural effusion.
Ann Lab Med
November 2014
Department of Hematology-Oncology, Busan Cancer Center, Pusan National University Hospital, Busan, Korea.
Establishment and characterization of mesenchymal stem cell-like clonal stem cells from mouse salivary glands.
Tissue Eng Part C Methods
May 2015
1 Department of Otorhinolaryngology-Head and Neck Surgery, Inha University School of Medicine, Incheon, Republic of Korea.
Successful therapy for radiation-induced salivary gland (SG) hypofunction is currently unavailable; however, tissue-specific stem cells are expected to be promising candidates for SG regeneration. Here, we present our method for the establishment of single cell-derived clonal stem cells from mouse SGs and describe their characteristics. Salivary gland-derived clonal stem cells (SGSCs) were isolated and expanded in vitro by a modified subfractionation culture method.
View Article and Find Full Text PDFAmylase-Producing Lung Cancer with a Positive Epidermal Growth Factor Receptor Mutation Treated With Gefitinib: A Case Report.
World J Oncol
February 2014
Department of Respiratory Medicine, Osaka Police Hospital, Osaka, Japan.
A 60-year-old woman was diagnosed with metastatic pulmonary adenocarcinoma (c-stage IV) with an L858R point mutation in the gene encoding epidermal growth factor receptor (EGFR). Serum amylase levels were elevated (1,531 IU/L) with the salivary-type enzyme dominating. First-line chemotherapy using carboplatin plus paclitaxel reduced serum amylase levels, although second-line gefitinib eventually failed to control tumor growth and hyperamylasemia after 4.
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