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[The mechanism of GSK-3β/CREB signaling pathway regulating macrophage pyroptosis and participating in the occurrence and development of diabetic foot ulcer].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
December 2024
Department of Endocrinology, The Fourth Hospital of Changsha(Changsha Hospital of Hunan Normal University), Changsha 410000, China.
Objective To investigate the role and possible mechanism of glycogen synthase kinase-3 beta (GSK-3β)/cAMP response element binding protein (CREB) signaling pathway in regulating macrophage pyroptosis in the pathogenesis and development of diabetic foot ulcer (DFU). Methods Thirty rats were randomly divided into control group, DFU group and GSK-3β inhibited group, with 10 rats in each group. Fasting blood glucose (FBG) was detected by dynamic blood glucose detector.
View Article and Find Full Text PDFFeatures, Treatments, and Therapeutic Outcomes of Peristomal versus Non-Peristomal Pyoderma Gangrenosum in 45 Patients with Inflammatory Bowel Disease: A Single-Institution Study, 2002 through 2021.
Skinmed
January 2025
Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, MA.
Pyoderma gangrenosum (PG) is the second most common skin manifestation reported in patients with inflammatory bowel disease (IBD). We performed a single-institution, retrospective study to summarize the clinical features and examine effective treatment regimens and outcomes of PG in IBD patients. We identified 45 patients who presented to our institute between January 1, 2002 and December 31, 2021 with the following criteria: (1) diagnosed with an active PG (ICD9: 686.
View Article and Find Full Text PDFFirst report on comprehensive genomic analysis of a multidrug-resistant Enterobacter asburiae isolated from diabetic foot infection from Bangladesh.
Sci Rep
January 2025
Department of Microbiology, University of Dhaka, Dhaka, 1000, Bangladesh.
Enterobacter asburiae (E. asburiae) is a gram-negative rod-shaped bacterium which has emerging significance as an opportunistic pathogen having high virulence pattern and drug resistant properties. In this study, we present the detailed analysis of the whole genome sequence of a multidrug-resistant (MDR) E.
View Article and Find Full Text PDFComputational and GC-MS screening of bioactive compounds from Thymus Vulgaris targeting mycolactone protein associated with Buruli ulcer.
Sci Rep
January 2025
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Buruli ulcer (BU) a neglected disease induced by the bacterium Mycobacterium ulcerans, predominantly impacts tropical and subtropical areas with its pathophysiology ascribed to the Mycolactone protein. Current antibiotics frequently prove insufficient to manage advanced or chronic ulcers and the rise of drug resistance presents a considerable challenge. This work aims to address these challenges by employing computational methods to identify therapeutic candidates from organic compounds, which may be developed into more effective therapies for Buruli ulcer.
View Article and Find Full Text PDFHyperbaric Oxygen Therapy Combined With Standard Wound Care Versus Standard Wound Care Alone in Patients With Diabetic Foot Ulcers: A Prospective Comparative Study.
Cureus
December 2024
General Surgery, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Mumbai, IND.
Article Synopsis
- Non-healing diabetic foot ulcers (DFUs) pose a risk for amputations, and hyperbaric oxygen therapy (HBOT) is explored as a potential treatment to enhance healing and lower amputation rates, although its effectiveness remains debated.
- A study was conducted with 60 adult patients with DFUs, randomly assigning them to two groups: one receiving HBOT alongside standard wound care (SWC) and the other receiving SWC alone, evaluating various outcomes over four weeks.
- Results indicated that patients receiving HBOT showed significantly greater improvements in pain, wound size, and healthy tissue formation, as well as a lower incidence of minor amputations compared to those with SWC alone.
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