Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132055 | PMC |
| http://dx.doi.org/10.1039/c3cc42098a | DOI Listing |
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