The use of thin-film solid-phase microextraction (SPME) as the sampling preparation step before direct analysis in real time (DART) was evaluated for the determination of two prohibited doping substances, cocaine and methadone, in urine samples. Results showed that thin-film SPME improves the detectability of these compounds: signal-to-blank ratios of 5 (cocaine) and 13 (methadone) were obtained in the analysis of 0.5 ng/ml in human urine. Thin-film SPME also provides efficient sample cleanup, avoiding contamination of the ion source by salt residues from the urine samples. Extraction time was established in 10 min, thus providing relatively short analysis time and high throughput when combined with a 96-well shaker and coupled with DART technique.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00216-013-6993-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Coma and confirmed epileptiform activity induced by Amanita pantherina poisoning.
Toxicon
December 2024
Bergamo Poison Center, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Amanita pantherina poisoning is a rare event poorly described. The clinical picture is usually associated with the one of A. muscaria, but A.
View Article and Find Full Text PDFMedications for Opioid Use Disorder in People Who Inject Substances: Reflection on the Potential Place of Morphine Sulfate as Substitution Treatment? Results of COSINUS Cohort Study.
Subst Use Misuse
December 2024
Centre d'étude des mouvements sociaux (Inserm U1276, /UMR CNRS 8044, /EHESS/Paris), Paris, France.
Background: Opioid Use Disorder (OUD) often provokes dramatic consequences in terms of increased morbi-mortality. Two medications have mainly been worldwide used for OUD (MOUD), buprenorphine and methadone. Recently, however, some reports have highlighted the use of Morphine Sulfate (MS) mainly obtained without a prescription but used as MOUD by opioid users and especially People Who Inject Substances (PWIS).
View Article and Find Full Text PDFStudy protocol for a randomized controlled trial to adapt a posttraumatic stress disorder intervention of patients with opioid-stimulant polysubstance use receiving methadone maintenance treatment.
BMC Psychiatry
December 2024
StartCare, Brooklyn, NY, USA.
Article Synopsis
- The THRIVE study aims to adapt a proven PTSD treatment for people using multiple substances while they receive methadone maintenance treatment (MMT), targeting those with a history of trauma and severe PTSD symptoms.
- The adapted treatment includes a condensed schedule of skill-building and narrative therapy sessions designed to help participants manage their PTSD and substance use more effectively.
- The study will involve a preliminary trial with 80 participants to evaluate the intervention's effectiveness and gather insights for future larger trials focused on improving outcomes for this vulnerable population.
Rapid Determination of Methamphetamine, Methylenedioxymethamphetamine, Methadone, Ketamine, Cocaine, and New Psychoactive Substances in Urine Samples Using Comprehensive Two-Dimensional Gas Chromatography.
Metabolites
November 2024
Center for Research on Multidimensional Separation Science, School of Chemical Sciences, Universiti Sains Malaysia, USM 11800, Penang, Malaysia.
Article Synopsis
- This study explores the effectiveness of a two-dimensional gas chromatography-flame ionization detection (GC×GC-FID) method for identifying 12 psychoactive drugs in urine, including popular substances like cocaine and methamphetamine.
- The method achieved clear separation of these drugs within 8 minutes using a specific column setup, demonstrating better results than traditional configurations.
- Validation showed high accuracy and precision for drug detection, with very low detection limits and effective recovery rates, proving its usefulness for quick forensic drug testing.
DRAMES and DTA databases: Complementary tools to monitor drug-related deaths in France.
Therapie
October 2024
Addictovigilance Dept, Grenoble-Alpes University Hospital, 38000 Grenoble, France.
Introduction: The DRAMES (décès en relation avec l'abus de médicaments et de substances) registry is a French database of drug-related deaths (medications or illicit drugs) among drug users. The DTA (décès toxiques par antalgiques) registry is a French database of analgesic-related deaths among people without a history of drug abuse. Both registries are based on the collection of data on deaths for which forensic toxicology experts have performed analyses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!