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Epithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosis.
EBioMedicine
January 2025
Department of Respiratory and Clinical Care Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. Electronic address:
Background: Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia with restrictive ventilation. Recently, the structural and functional defects of small airways have received attention in the early pathogenesis of IPF. This study aimed to elucidate the characteristics of small airway epithelial dysfunction in patients with IPF and explore novel therapeutic interventions to impede IPF progression by targeting the dysfunctional small airways.
View Article and Find Full Text PDFPenile Reconstruction with Radial Forearm Free Flap-Present State of the Art.
Indian J Plast Surg
December 2024
Department of Plastic and Reconstructive Surgery, Amrita Hospital, Faridabad, Haryana, India.
Article Synopsis
- Patients with penile defects, whether congenital or acquired, experience significant psychological distress, and the free radial artery forearm flap method has emerged as a preferred technique for reconstruction.
- A retrospective study over 16 years reviewed various cases, modifying the initial design to enhance urethral function and stability in the procedure.
- Results indicated that most patients regained sensation and could urinate standing; however, some experienced complications, and aesthetic outcomes varied, highlighting the technique's potential for effective rehabilitation.
Repairing muscle with broccoli-derived sulforaphane: A preclinical evaluation for the treatment of mitochondrial myopathies.
Drug Discov Today
December 2024
Department of Health Sciences and Biostatistics, Swinburne University of Technology, Melbourne, Australia. Electronic address:
Skeletal muscle health relies on the production of adenosine triphosphate (ATP) in the mitochondria. ATP production is accompanied by oxidative phosphorylation, which generates reactive oxygen species (ROS). When there is an imbalance in ROS levels, oxidative stress and subsequent mitochondrial dysfunction, mitochondrial myopathies including sarcopenia, chronic progressive external ophthalmoplegia, and proximal myopathy can result.
View Article and Find Full Text PDFProximity to Practice: The Role of Technology in the Next Era of Assessment.
Perspect Med Educ
December 2024
Faculty of Education, Queen's University, Canada.
The integration of technology into health professions assessment has created multiple possibilities. In this paper, we focus on the challenges and opportunities of integrating technologies that are used during clinical activities or that are completed by raters after a clinical encounter. In focusing on technologies that are more proximal to practice, we identify tradeoffs with different data collection approaches.
View Article and Find Full Text PDFAnalysis of posterior hip joint impingement about developmental dysplasia of the hip after total hip arthroplasty.
Clin Biomech (Bristol)
December 2024
Department of Orthopedic Surgery, Hiroshima University Hospital Graduate School of Biomedical and Health Sciences, Hiroshima City, Hiroshima Prefecture, Japan.
Background: Total hip arthroplasty is the preferred treatment for advanced hip osteoarthritis, yet complications like hip dislocation (0.2 %-10 %) persist due to factors such as implant design, positioning, surgical technique, and patient-specific conditions. Impingement between prosthetic components or the acetabulum and proximal femur is a primary cause of instability.
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