AI Article Synopsis
- Molecular chaperone-based vaccines, particularly the Hsp70 fusion vaccine, are effective in activating T cell immunity against cancer and show promise in treating tumor-bearing mice.
- These vaccines can retain more tumor antigens compared to other methods and can be tailored to target specific drug-resistant cancer cells, including those related to ovarian cancer stem cells.
- Combining Hsp70 fusion vaccines with therapies like ionizing radiation or hyperthermia may enhance treatment effectiveness for resistant cancer types.
Article Abstract
Molecular chaperone-based vaccines offer a number of advantages for cancer treatment. We have discussed the deployment of a vaccine prepared by gentle isolation of Hsp70 from tumour dendritic cell fusions (Hsp70 fusion vaccine). The vaccine was highly effective in triggering specific T cell immunity and in the treatment of tumour-bearing mice and the preparation was shown to retain an increased amount of tumour antigens compared to other chaperone-based isolates. This approach has the further advantage that tumour sub-populations could be used to prepare the Hsp70 fusion vaccine. Cellular fusion vaccines were made to specifically target drug-resistant cancer cells and tumour cell populations enriched in ovarian cancer stem cells (CSC). Such vaccines showed enhanced capacity to trigger T cell immunity to these resistant ovarian carcinoma populations. We have discussed the potential of using the cellular and Hsp70 fusion vaccine approaches in therapy of treatment-resistant cancer cells and its deployment in combination with ionising radiation or hyperthermia to enhance the effectiveness of both forms of therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100618 | PMC |
| http://dx.doi.org/10.3109/02656736.2013.792126 | DOI Listing |
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