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| http://dx.doi.org/10.3109/02699206.2013.789085 | DOI Listing |
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Building the Capacity of Young Professionals in Family Planning to Publish: Insights from the ICFP2022 WHO Scientific Writing, Mentoring and Coaching Course.
Contraception
January 2025
UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP) Department of Sexual and Reproductive Health and Research (SRH) World Health Organization, Geneva, Switzerland.
Objectives: We describe the development, delivery, and evaluation of a program to support junior professionals to publish their work in a scientific journal.
Study Design: Conference delegates with an accepted abstract at the International Conference on Family Planning (ICFP), self-identifying as junior professionals and from a low- or middle-income country (LMIC) or working predominantly in LMIC settings, were eligible for the program. The program involved: (i) Four face-to-face workshops at ICFP from the 14 to 17 of November 2022; (ii) mentoring meetings at ICFP; (iii) a six-month post-conference online coaching program; and (iv) post-conference learning webinars from December 2022 to May 2023.
Medial Opening Wedge Osteotomy for Early Osteoarthritis of the Knee With Dr. Saigal's Plate: A Case Report With Review of Literature.
Cureus
December 2024
Department of Orthopaedics and Traumatology, All India Institute of Medical Sciences, Raipur, Raipur, IND.
Article Synopsis
- Knee pain often involves varus deformity and unicompartmental osteoarthritis, where high tibial valgus osteotomy (HTO) has emerged as an effective treatment option to delay joint replacement.
- A case report highlighted two patients with bilateral knee arthritis who underwent medial opening-wedge high tibial osteotomy using Dr. Saigal's plate, both achieving good range of motion and minimal complications post-surgery.
- Comprehensive evaluations, including radiological assessments and specific surgical techniques like the Miniaci Method, were employed to ensure successful outcomes, with both patients showing significant improvement after one year.
Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trial.
EClinicalMedicine
January 2025
Canadian Cancer Trials Group, Queen's University, Kingston, ON, Canada.
Background: Dual inhibition of cytotoxic T-lymphocyte associated protein 4 (CTLA-4) and programmed death ligand 1 (PD-L1) has been shown to be an effective treatment strategy in many cancers. We sought to determine the objective response rate of combination durvalumab (D) plus tremelimumab (TM) in parallel cohorts of patients with carefully selected rare cancer types in which these agents had not previously been evaluated in phase II trials and for which there was clinical or biological rationale for dual immune checkpoint inhibitor therapy to be active.
Methods: We designed a multi-centre, non-blinded, open-label phase II basket trial with each of the following 8 rare cancers considered a separate phase II trial: salivary carcinoma, carcinoma of unknown primary (CUP) with tumour infiltrating lymphocytes and/or expressing PD-L1, mucosal melanoma, acral melanoma, osteosarcoma, undifferentiated pleomorphic sarcoma, clear cell carcinoma of the ovary (CCCO) or squamous cell carcinoma of the anal canal (SCCA).
IAPRD new consensus classification of myoclonus.
Parkinsonism Relat Disord
December 2024
Department of Neurology, Mayo Clinic, 13400 East Shea Blvd, Scottsdale, AZ, 85259, USA. Electronic address:
Introduction: Recent new advances in myoclonus characterization and etiology justify an update of the 40-year-old respected classification of myoclonus proposed by Marsden, Hallett, and Fahn. New advances include genetic studies and clinical neurophysiology characterization.
Methods: The IAPRD appointed an expert panel to develop a new myoclonus classification.
Background: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides a comprehensive assessment of health and risk factor trends at global, regional, national, and subnational levels. This study aims to examine the burden of diseases, injuries, and risk factors in the USA and highlight the disparities in health outcomes across different states.
Methods: GBD 2021 analysed trends in mortality, morbidity, and disability for 371 diseases and injuries and 88 risk factors in the USA between 1990 and 2021.
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