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Availability, price and affordability of essential medicines for managing cardiovascular disease in Addis Ababa, Ethiopia.
Sci Rep
December 2024
School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Access to health care is a fundamental human right. However, nearly one-third of the global population have no access to it. This magnitude is even much worse in low- and middle-income countries.
View Article and Find Full Text PDFAnalysis of the pattern of drug use using WHO core drug indicators among general OPD patients in rural Puducherry.
J Family Med Prim Care
November 2024
Department of Community Medicine, Indira Gandhi Medical College and Research Institute, Puducherry, India.
Background: Prescription auditing is a crucial tool for evaluating a range of concerns, including injectable usage, polypharmacy, the use of generic names, and the quality of treatment given to patients in primary care facilities. The objective of the study was to assess, using WHO core drug use indicators, the drug use patterns of general outpatients (OPD) at a rural healthcare facility.
Materials And Methods: A cross-sectional study was conducted in a rural peripheral health centre in Puducherry for a period of one year from September 2019 to August 2020.
Pediatric uveitis.
J Family Med Prim Care
November 2024
Flinders University College of Medicine and Public Health, Adelaide, Australia.
Up to 10% of uveitis cases occur in children, with notable implications due to the risk of chronicity and vision loss. It can result from infections, autoimmune and autoinflammatory diseases, trauma, or masquerade syndromes. Primary care providers are vital in early detection, symptom management, and timely specialist referral.
View Article and Find Full Text PDFNasal absorption of oxycodone predicted using a novel computational fluid dynamics-physiologically based pharmacokinetic model.
J Control Release
December 2024
Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Oxycodone hydrochloride (HCl) extended release (ER) tablet is an abuse-deterrent formulation that uses a physical barrier to make it more difficult to crush tablets prior to abuse via various routes. A previously conducted in vivo pharmacokinetics (PK) study showed that particle size exhibited significant effects on PK. Here, a computational modeling study using a novel combined computational fluid dynamics and physiologically based PK model was applied to better understand the mechanisms that produce differences in PK according to particle size and formulation type for nasally insufflated oxycodone HCl immediate release (IR) and ER ts.
View Article and Find Full Text PDFPhylogenetic diversity and morphological characterization of cordycipitaceous species in Taiwan.
Stud Mycol
December 2024
Department of Plant Pathology and Microbiology, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan.
Species classified in () include multiple entomopathogenic fungi. Numerous changes have recently occurred in the nomenclature of cordycipitaceous fungi due to the single naming system proposed for pleomorphic fungi in 2011. Species of are widely applied as herbal medicines, especially in Asian cultures.
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