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B and C hepatitis viruses, HLA-DQ1 and -DR3 alleles and autoimmunity in patients with hepatocellular carcinoma.
J Hepatol
April 2002
O.U. Immunohaematology and Transfusion Division, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy.
Background/aims: Hepatitis B and C involvement in hepatocellular carcinoma has been well established, but as yet not that of the human lymphocyte antigen (HLA) complex. To study viral, HLA and tumour interrelationships, 105 patients were evaluated for prevalence of viral markers and 161 patients, including 99 of the previous ones, for HLA allele frequency; the other 52 patients served as controls.
Methods: Immunoassays, molecular assays, microlymphocytotoxicity.
HLA-DQw1 compatibility and cadaveric renal allograft survival.
Transplantation
July 1990
Department of Laboratory Medicine, Ottawa General Hospital, University of Ottawa Health Sciences Center.
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