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The (pro)renin receptor and body fluid homeostasis. | LitMetric

The (pro)renin receptor and body fluid homeostasis.

Am J Physiol Regul Integr Comp Physiol

Department of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Published: July 2013

The renin-angiotensin system (RAS) has long been established as one of the major mechanisms of hypertension through the increased levels of angiotensin (ANG) II and its resulting effect on the sympathetic nerve activity, arterial vasoconstriction, water reabsorption, and retention, etc. In the central nervous system, RAS activation affects body fluid homeostasis through increases in sympathetic nerve activity, water intake, food intake, and arginine vasopressin secretion. Previous studies, however, have shown that ANG II can be made in the brain, and it could possibly be through a new component called the (pro)renin receptor. This review intends to summarize the central and peripheral effects of the PRR on body fluid homeostasis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116410PMC
http://dx.doi.org/10.1152/ajpregu.00209.2013DOI Listing

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