AI Article Synopsis
- The study examines the role of placental growth factor (PlGF) and its antagonist, sFlt-1, in predicting long-term outcomes for patients with stable coronary artery disease (CAD).
- Researchers enrolled 464 patients and analyzed blood samples to measure PlGF and sFlt-1 levels, finding a correlation between higher PlGF/sFlt-1 ratios and increased risk of all-cause death and total cardiovascular events during a median follow-up of 3.3 years.
- The results indicate that the PlGF/sFlt-1 ratio is an independent predictor for all-cause death in these patients, highlighting its potential significance in CAD prognosis.
Article Abstract
Objective: To investigate the predictive values of placental growth factor (PlGF) and its endogenous antagonist, soluble fms-like tyrosine kinase-1 (sFlt-1), for the long-term prognosis of patients with stable coronary artery disease (CAD). Both PlGF and sFlt-1 play important roles in the pathological mechanisms of atherosclerosis. We recently demonstrated that the plasma levels of these molecules are correlated with the severity of coronary atherosclerosis.
Methods: We enrolled 464 patients with stable CAD who consecutively underwent coronary angiography. Baseline blood samples were collected from the femoral artery immediately before coronary angiography (after the administration of 20 units of heparin), and the plasma levels of PlGF and sFlt-1 were measured. A Cox proportional hazard regression analysis was performed to evaluate the relationship between these parameters and the occurrence of all-cause death (ACD) and total cardiovascular events (TCVE) during a median follow-up of 3.3 years.
Results: A total of 31 ACDs and 51 TCVEs occurred. Patients with higher PlGF/sFlt-1 ratios (>4.22×10(-2)) had a significantly higher risk of both ACD and TCVE than patients with lower ratios (<4.22×10(-2)) (hazard ratio [HR]: 3.32, 95% confidence interval [CI]: 1.43 to 7.72, p=0.005, and HR: 2.23, 95% CI: 1.23 to 4.03, p=0.008, respectively). A multivariate analysis showed the PlGF/sFlt-1 ratio to be an independent predictor for ACD, but not TCVE.
Conclusion: The baseline PlGF/sFlt-1 ratio is an independent predictor of long-term adverse outcomes in patients with stable CAD.
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| http://dx.doi.org/10.2169/internalmedicine.52.9073 | DOI Listing |
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