Simple, accurate and precise spectrophotometric methods have been developed for the determination of saxagliptin in bulk and dosage forms. The proposed methods are based on the charge transfer complexes of saxagliptin with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). All the variables were studied to optimize the reactions' conditions. Beer's law was obeyed in the concentration ranges of 50-300 μg/ml and 10-110 μg/ml with DDQ and TCNQ, respectively. The developed methods were validated and proved to be precise and accurate for the quality control of the saxagliptinin its pharmaceutical dosage form.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615277 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Development and validation of a UV-Vis spectrophotometric method for estimation of total content of chalcone.
MethodsX
June 2025
Observatory of Drug-Herb Interactions, Faculty of Pharmacy, University of Coimbra, Health Science Campus, Azinhaga Santa Comba, Coimbra, Portugal.
In this study, a straightforward spectrophotometric method was developed for quantifying the total content of chalcones in a sample. The method exhibits linearity, accuracy, precision, repeatability, and enables the estimation of total chalcone content in trans-chalcone equivalents for a sample diluted in carbon tetrachloride and added to antimony pentachloride. The analytical wavelength was determined to be 390 nm.
View Article and Find Full Text PDFComparative evaluation of various DNA extraction methods and analysis of DNA degradation levels in commercially marketed Chestnut rose juices and beverages.
BMC Biotechnol
January 2025
CAIQ Center for Biosafety, Chuangyi Rd, Yazhou District, Sanya, Hainan Province, 572024, China.
Background: Food safety is a significant global study subject that is strongly intertwined with human life and well-being. The utilization of DNA-based methods for species identification is a valuable instrument in the field of food inspection and regulation. It is particularly significant for traceability purposes, as it enables the monitoring of a specific item at every level of the food chain regulation.
View Article and Find Full Text PDFBoosting nutritional value: the role of iron fortification in meat and meat products.
Biometals
January 2025
Faculty of Public Health, Poornima University, Jaipur, Rajasthan, India.
Iron deficiency is a widespread nutritional problem affecting millions of people globally, leading to various health issues including anemia. Iron fortification of meat and meat products has emerged as an effective strategy to combat this issue. This review explores the process and benefits of iron fortification, focusing on the types of iron compounds suitable for fortification, such as ferrous sulfate and ferric pyrophosphate, their bioavailability, and their impact on the sensory and nutritional qualities of meat products.
View Article and Find Full Text PDFLanthanide ion-based metal-organic framework as an effective tri-mode nanoprobe for alcoholic content detection.
Mikrochim Acta
January 2025
School of Chemistry and Chemical Engineering, Yantai University, Yantai, 264005, China.
A lanthanide ion-based metal-organic framework (Eu-TATAB nanorods) was designed and synthesized as an effective tri-mode nanoprobe for sensitive and portable detection of ethanol content in a water-ethanol mixture. The assay was based on the responsive properties of Eu-TATAB nanorods to ethanol stimulus and their adaptive encapsulation capability towards optically active lanthanides. With the addition of ethanol to the Eu-TATAB nanorods, the structure was destroyed, resulting in a decrease in luminescence, electrochemiluminescence, and ultraviolet-visible spectrophotometric signals by perturbing energy transfer in the Eu-TATAB nanorods.
View Article and Find Full Text PDFWhitening: is Omnichroma universal composite unchanging? Spectrophotometric evaluation.
J Clin Exp Dent
December 2024
Department of Surgical Sciences, Pediatrics and Gynecology, University of Verona, P.le L.A.Scuro, 10, 37134 Verona, Italy.
Background: This study aimed to evaluate the color stability of Class V anterior restorations with universal composite after professional bleaching using a spectrophotometer.
Material And Methods: Class V cavities were prepared and restored with universal composite in twenty-eight extracted anterior teeth. One week after restoration, color analysis was performed using the spectrophotometer.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!