AI Article Synopsis
- Around 50% of drugs in use are chiral compounds, with about 90% of them being racemates, which are mixtures of two enantiomers that differ in biological activity despite having the same chemical structure.
- Chiral drugs can show significant variations in how they interact with the body, affecting their pharmacology, toxicology, and metabolism, making it crucial to separate and analyze these compounds effectively.
- The article reviews the terminology and effects of chiral drugs and discusses various methods for chiral separation used in the pharmaceutical industry and clinical settings.
Article Abstract
About more than half of the drugs currently in use are chiral compounds and near 90% of the last ones are marketed as racemates consisting of an equimolar mixture of two enantiomers. Although they have the same chemical structure, most isomers of chiral drugs exhibit marked differences in biological activities such as pharmacology, toxicology, pharmacokinetics, metabolism etc. Some mechanisms of these properties are also explained. Therefore, it is important to promote the chiral separation and analysis of racemic drugs in pharmaceutical industry as well as in clinic in order to eliminate the unwanted isomer from the preparation and to find an optimal treatment and a right therapeutic control for the patient. In this article, we review the nomenclature, pharmacology, toxicology, pharmacokinetics, metabolism etc of some usual chiral drugs as well as their mechanisms. Different techniques used for the chiral separation in pharmaceutical industry as well as in clinical analyses are also examined.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614593 | PMC |
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