Aim: To explore hereditability of gastric cancer in Wuwei city.
Methods: A case-control study was used to investigate 251 gastric cancer families located in Wuwei city. Li-Mantel-Gan and Falconer regression methods were used to calculate segregation ratios and hereditability.
Results: The segregation ratio in Wuwei families was 0.0774, the hereditability of class I kinfolks and class II kinfolks were respectively 22.91% and 20.07%.
Conclusion: The segregation ratio of gastric cancer in Wuwei was significantly lower than for mono-genetic diseases (0.25), corresponding better with a model of polygenetic diseases. The genetic susceptibility factor accounted for about 1/5-1/4 in the formation of gastric cancer familial aggregation. Mi DH, Chen XP, Luo HZ Research on hereditability of gastric cancer in Wuwei city.
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