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| http://dx.doi.org/10.5489/cuaj.220 | DOI Listing |
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Evaluation of double-balloon enteroscopy in the management of type 1 small bowel vascular lesions (angioectasia): a retrospective cohort study.
BMC Gastroenterol
January 2025
Independent Researcher, İzmir, Turkey.
Background: Small-bowel angioectasia is commonly diagnosed and managed using double-balloon enteroscopy; however, rebleeding rates can vary significantly. This study aimed to identify and evaluate the clinical predictors of rebleeding in patients with small-bowel angioectasia.
Methods: This retrospective study focused on adult patients who underwent endoscopic management for small bowel vascular lesions (SBVLs).
A cell-free biosensor signal amplification circuit with polymerase strand recycling.
Nat Chem Biol
January 2025
Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.
Cell-free systems are powerful synthetic biology technologies that can recapitulate gene expression and sensing without the complications of living cells. Cell-free systems can perform more advanced functions when genetic circuits are incorporated. Here we expand cell-free biosensing by engineering a highly specific isothermal amplification circuit called polymerase strand recycling (PSR), which leverages T7 RNA polymerase off-target transcription to recycle nucleic acid inputs within DNA strand displacement circuits.
View Article and Find Full Text PDFAssessing drywell designs for managed aquifer recharge via canals and repurposed wells.
Sci Rep
January 2025
USDA, ARS, Sustainable Agricultural Water Systems (SAWS) Unit, UC Davis, 239 Hopkins Road, Davis, CA, 95616, USA.
This study explores innovative drywell designs for managed aquifer recharge (MAR) in agricultural settings, focusing on smaller diameter and deeper drywells, including the repurposing of dried or abandoned wells. Numerical simulations assessed the impact of drywell diameter (5-120 cm), depth (15-55 m), screen height, and subsurface heterogeneity on infiltration (I) and recharge (R) volumes over a one-year period under constant head conditions. Results indicate that smaller diameter drywells can effectively infiltrate and recharge significant water volumes.
View Article and Find Full Text PDFHypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms.
NPJ Biofilms Microbiomes
January 2025
Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Biológica "Ranwel Caputto", Córdoba, Argentina.
Biofilms are critical in the persistence of Pseudomonas aeruginosa infections, particularly in cystic fibrosis patients. This study explores the adaptive mechanisms behind the phenotypic switching between Small Colony Variants (SCVs) and revertant states in P. aeruginosa biofilms, emphasizing hypermutability due to Mismatch Repair System (MRS) deficiencies.
View Article and Find Full Text PDFRefining PREVENT prediction models for 10-year risk of cardiovascular disease using measures of anxiety and depression.
CMAJ
January 2025
Schools of Health and Wellbeing (Nakada, Pell, Ho), and Cardiovascular and Metabolic Health (Welsh, Celis-Morales), University of Glasgow, Glasgow, UK; Human Performance Laboratory, Education, Physical Activity and Health Research Unit (Celis-Morales), Universidad Católica del Maule, Talca, Chile; Centro de Investigación en Medicina de Altura (CEIMA) (Celis-Morales), Universidad Arturo Prat, Iquique, Chile.
Background: Anxiety and depression are associated with cardiovascular disease (CVD). We aimed to investigate whether adding measures of anxiety and depression to the American Heart Association Predicting Risk of Cardiovascular Disease Events (PREVENT) predictors improves the prediction of CVD risk.
Methods: We developed and internally validated risk prediction models using 60% and 40% of the cohort data from the UK Biobank, respectively.
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