Rh-catalyzed direct enantioselective alkynylation of α-ketiminoesters.

Chemistry

Graduate School of Pharmaceutical Sciences, Kyushu University, CREST, Maidaashi Higashi-ku, Fukuoka, 812-8582, Japan.

Published: June 2013

A green way to amino acids: α-Tetrasubstituted α-amino acid derivatives are formed in high yield and enantioselectivity by using a Rh-catalyzed enantioselective alkynylation of α-ketiminoesters. This reaction, which involves a proton transfer and can be conducted at room temperature, has high substrate scope (see scheme; Cbz = benzyloxycarbonyl, Fmoc = 9-fluorenylmethyloxycarbonyl).

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http://dx.doi.org/10.1002/chem.201301237DOI Listing

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