Steroidal glycosides from Reineckia carnea herba and their antitussive activity.

Planta Med

Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.

Published: June 2013

Two new steroidal glycosides, 1α,3α-dihydroxy-5β-pregn-16-en-20-one 3-O-α-L-rhamnopyranoside (1) and 1β,3β,27-trihydroxycholest-16-en-22-one 1,3-di-O-α-L-rhamnoside (2), along with seven known steroidal glycosides (3-9), were isolated from Reineckia carnea herba. Their structures were determined by detailed analysis of their 1D- and 2D-NMR and MS spectra. Compound 9 was isolated for the first time from the Reineckia genus. Except for 8, compounds 2, 3, 4, 5, 6, 7, and 9 displayed clear in vitro antitussive activity.

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http://dx.doi.org/10.1055/s-0032-1328556DOI Listing

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