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An economical synthesis of benzodiazepines using ACT@IRMOF core-shell as a potential eco-friendly catalyst through the activated carbon of thymus plant (ACT).
Nanoscale Adv
December 2024
Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University 6517838683 Hamadan Iran
Here, a straightforward design is employed to synthesize a nanocatalyst based on a carbon-activated modified metal-organic framework using the solvothermal method. This work presents a simple and practical approach for producing the activated carbon derived from the Thymus plant (ACT) modified with amine-functionalized isoreticular metal-organic framework-3 (IRMOF-3) to create an ACT@IRMOF-3 core-shell structure. Successful functionalization was confirmed through N adsorption isotherms, FT-IR, FE-SEM, TEM, EDS, elemental mapping, TGA, and XRD analysis.
View Article and Find Full Text PDFAnxiogenic-like effects of coumarin, possibly through the GABAkine interaction pathway: Animal studies with in silico approaches.
Behav Brain Res
March 2025
Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh; Bioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd., Gopalganj 8100, Bangladesh; Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh. Electronic address:
Background: Anxiety disorder is the most common mental illness and a major contributor to impairment. Thus, there is an urgent need to find novel lead compounds to mitigate anxiety. It is widely recognized that the neurobiology of anxiety-related behavior involves GABAergic systems.
View Article and Find Full Text PDFLamotrigine as a preventive agent against recurrent catatonia in adult-onset Niemann-Pick Type-C disease: a case report.
Neurocase
December 2024
Department of Psychiatry, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Article Synopsis
- - Niemann-Pick Type-C (NPC) disease can lead to serious neuropsychiatric issues, including catatonia, which doesn't always respond well to standard treatments like antipsychotics.
- - A patient with adult-type NPC developed catatonia that persisted despite various medications, but improved significantly with electroconvulsive therapy (ECT).
- - Combining ECT with lorazepam managed the catatonia, and adding lamotrigine led to full remission for eight months, suggesting lamotrigine's potential benefits in treating recurrent catatonia.
Anxiety modulators elicit different behavioral outcomes in adult zebrafish: Emphasis on homebase-related parameters and spatio-temporal exploration.
Pharmacol Biochem Behav
January 2025
Laboratory of Experimental Neuropsychobiology, Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Center, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil; Graduate Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS 97105-900, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA. Electronic address:
Anxiety is an emotion that represents a crucial anticipatory reaction of aversive stimuli, with clinical relevance in cases of disproportional and severe occurrences. Although distinct animal models have contributed to elucidate anxiety-related mechanisms, the influence of anxiogenic and anxiolytic modulations on both locomotion and exploration-related parameters in the open field test (OFT) is not fully elucidated. Here, we aimed to assess the influence of anxiogenic and anxiolytic manipulations on the exploratory dynamics of adult zebrafish (Danio rerio) focusing on homebase-related behaviors.
View Article and Find Full Text PDFEnabling systemic identification and functionality profiling for Cdc42 homeostatic modulators.
Commun Chem
November 2024
Department of Chemistry and Biochemistry, College of Arts and Sciences, University of South Carolina, Columbia, SC, USA.
Maintaining body homeostasis is the ultimate key to health. There are rich resources of bioactive materials for the functionality of homeostatic modulators (HMs) from both natural and synthetic chemical repertories. HMs are powerful modern therapeutics for human diseases including neuropsychiatric diseases, mental disorders, and drug addiction (e.
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