AI Article Synopsis
- A cross-sectional study analyzed 469 HIV-infected patients to determine how their mitochondrial haplogroups relate to AIDS progression.
- Patients with mitochondrial cluster HV and haplogroup H had higher chances of not progressing to AIDS, with haplogroup H showing a particularly significant odds ratio in the analysis.
- The findings indicate that mitochondrial haplogroups could influence the progression of AIDS, potentially offering insights for future research or treatment approaches.
Article Abstract
We performed a cross-sectional study in 469 HIV-infected patients, whose mitochondrial haplogroups were genotyped to study their association with the clinical pattern of AIDS progression. The chance of not having an AIDS progression was 1.45 [95% of confidence interval (CI) = 1.02 to 2.05, P = 0.035) times greater in patients with cluster HV and 1.51 (95% CI = 1.06 to 2.18, P = 0.021) times greater in patients with haplogroup H. However, we only found significant values for haplogroup H (odds ratio = 1.52, 95% CI = 1.01 to 2.32, P = 0.049) in an ordinal logistic regression adjusted by gender, age at HIV infection, intravenous drug users, and hepatitis C virus infection. These data suggest that mitochondrial haplogroups might play a significant role in AIDS progression.
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| http://dx.doi.org/10.1097/QAI.0b013e3182893f74 | DOI Listing |
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