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Low-dose sugammadex reverses moderate rocuronium-induced neuromuscular block in horses.
Equine Vet J
January 2025
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Article Synopsis
- Neuromuscular block (NMB) during anesthesia can lead to prolonged recovery times; traditionally, reversal has been done with neostigmine/atropine, which can have side effects, while sugammadex offers a more effective alternative without those complications.
- A study tested low-dose sugammadex (200 mg) on 14 anesthetized horses to compare recovery times from NMB caused by rocuronium, finding that recovery was significantly faster with sugammadex (4 minutes) compared to spontaneous recovery (21 minutes).
- Results highlighted that sugammadex not only reduced recovery time but also the duration of NMB, with no instances of recurarisation observed, though the study's findings
Evaluation of Sugammadex Dosing for Neurological Examination in the Emergency Department.
J Pharm Pract
August 2024
Department of Pharmacy Services, University of Kentucky HealthCare, Lexington, KY, USA.
Prolong effects of non-depolarizing neuromuscular blocking agents after rapid sequence intubation may prevent meaningful neurological examination, delaying appropriate diagnosis and neurosurgical intervention. Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium. The objective of this study was to evaluate low- (2 mg/kg) vs standard-dose (4 mg/kg) sugammadex for rocuronium-induced deep neuromuscular blockade reversal in the emergency department (ED) by achieving a post-treatment train-of-four (TOF) of 4 to facilitate neurological examination.
View Article and Find Full Text PDFPOLG-related mitochondrial disease is a rare mitochondrial disorder that is potentially associated with anaesthetic complications such as propofol-related infusion syndrome. A 19-year-old man with mitochondrial DNA deletions and POLG-related disorders presented for an elective robotic Heller-Dor myotomy for the treatment of oesophageal pseudo-achalasia associated with severe gastro-oesophageal reflux. The fasting period was minimised to reduce the risk of metabolic stress.
View Article and Find Full Text PDFQuantitative Neuromuscular Monitoring With Train-of-Four Ratio During Elective Surgery: A Prospective, Observational Study.
J Patient Saf
August 2021
From the Department of Anesthesiology and Intensive Care, Mersin University Faculty of Medicine, Mersin, Turkey.
Objectives: Postoperative residual neuromuscular block (PRNB) is a serious problem that can cause death after surgery. It was aimed to evaluate the adequacy of neuromuscular block (NMB) during endotracheal intubation and the adequacy of neuromuscular recovery during clinically extubation decision and follow-up with the train-of-four ratio (TOFR) using quantitative monitoring.
Methods: This study has a prospective-observational single-blind study design.
Water Pollution and Environmental Concerns in Anesthesiology.
J Med Syst
August 2020
Department of Anesthesiology, University of Vermont Larner College of Medicine, 111 Colchester Avenue, Burlington, VT, USA.
Article Synopsis
- Medications used in anesthesia can contaminate water supplies, posing risks to ecological systems, yet little research exists on which specific drugs enter waste and their environmental effects.
- Recent studies focused on anesthesiology's solid waste and greenhouse gas emissions, but the impact of drug-related water pollution hasn't been fully explored.
- In analyzing administration data from the University of Vermont Medical Center, the study identified commonly used medications and their potential environmental risks, highlighting the need for more research on chronic low-dose exposure effects on aquatic life.
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