Examination of 84 essentially healthy men, aged 19 to 34 years, by the rebreathing method showed that in various test subjects the reserve time prior to decompensation was in the range 5 to 9 min. A certain change was seen 1-2 min before termination of the test due to acute respiratory failure. This change included an increase in the minute respiration volume above 40 1/min and its relative increment by 10 1/min or over when compared to the preceding minute. The test time varied from 4 to 8 min. Analysis of the data using the cardiorespiratory index which is equal to the product of heart rate by systolic arterial pressure divided by the minute respiration volume helped to discriminate test subjects with satisfactory, good and very good tolerance of the rebreathing test.
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Arterioscler Thromb Vasc Biol
January 2025
Cardiovascular Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. (A.S., R.M.F., F.M.v.H.).
Background: Binding of ANGPTL (angiopoietin-like protein)-3 to ANGPTL8 generates a protein complex (ANGPTL3/8) that strongly inhibits LPL (lipoprotein lipase) activity, as compared with ANGPTL3 alone, suggesting that ANGPTL3/8 concentrations are critical for the regulation of circulation lipoprotein concentrations and subsequent increased coronary heart disease (CHD) risk. To test this hypothesis in humans, we evaluated the associations of circulating free ANGPTL3 and ANGPTL3/8 complex concentrations with lipoprotein concentrations and CHD risk in 2 prospective cohort studies.
Methods: Fasting blood samples were obtained in conjunction with the baseline evaluation of 9479 subjects from 2 population-based Swedish cohorts of middle-aged men and women.
Bull World Health Organ
February 2025
LSE Health, Department of Health Policy, London School of Economics and Political Science, Houghton Street, London, WC2A 2AE, London, England.
Objective: To map how social, commercial, political and digital determinants of health have changed or emerged during the recent digital transformation of society and to identify priority areas for policy action.
Methods: We systematically searched MEDLINE, Embase and Web of Science on 24 September 2023, to identify eligible reviews published in 2018 and later. To ensure we included the most recent literature, we supplemented our review with non-systematic searches in PubMed® and Google Scholar, along with records identified by subject matter experts.
Heliyon
January 2025
School of Digital Science, Universiti Brunei Darussalam, Gadong BE1410, Brunei Darussalam.
Microlearning has become increasingly popular not only in education sector but also in corporate sector in recent years. However, its definition and didactics conceptualization, integration into instruction design, and effects on learning outcomes remain largely underexplored in terms of synthesized findings. Consequently, challenges persist in clarifying microlearning definition, and didactics, and designing effective microlearning instruction to yield improved learning outcomes.
View Article and Find Full Text PDFInt J Dev Disabil
May 2023
School of Sport, Exercise Science and Rehabilitation, University of Essex, Colchester, Essex, UK.
Autistic individuals often display social-communicative differences affecting aspects of daily living. The present study assessed the feasibility and potential efficacy of a dance-based exergame for enhancing autistic children's social-communication skills. A mixed method, within-subject, pre-test/post-test study design was employed.
View Article and Find Full Text PDFInt J Dev Disabil
June 2023
School of Education Science, Xinjiang Normal University, Urumqi, China.
Executive dysfunction has been widely reported in children with autism spectrum disorder (ASD). Although studies have demonstrated the intervention effect of sports game and pretend play on children's executive function, few studies have examined the effect of Comprehensive games, and similar studies in children with ASD are scarce. In order to investigate the effect of different games on the executive functions of preschool children with ASD, 24 preschool children with ASD were selected in this study.
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