Probestin is a potent aminopeptidase N (APN) inhibitor originally isolated from the bacterial culture broth. Here, we report probestin synthesis by solid phase peptide synthesis (SPPS) method and evaluated its activity to inhibit angiogenesis using a chicken embryo chorioallantoic membrane (CAM) assay and a CAM tumor xenograft model. Results from these studies demonstrate that probestin inhibits the angiogenic activity and tumor growth.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172075 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2013.04.031 | DOI Listing |
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