Superficial siderosis of the central nervous system (CNS) is a rare disorder caused by deposition of hemosiderin in neuronal tissue in the subpial layer of the CNS due to slow subarachnoid or intraventricular hemorrhage. The most common neurologic manifestations include progressive gait ataxia, sensorineural hearing loss, and corticospinal tract signs. We present a case of superficial siderosis in a 43-year-old man who presented to the Emergency Department with sudden onset bilateral visual deterioration and a loss of consciousness. A hemorrhagic giant prolactinoma was diagnosed based on brain CT scan, T1-weighted MRI, and an endocrine blood examination. Susceptibility-weighted non-contrast MRI showed pathognomonic signs of superficial siderosis in the form of a hypointensity rim surrounding the brainstem, cerebellar fissures, and cranial nerves VII and VIII. This report demonstrates that superficial siderosis can be caused by pituitary apoplexy.
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http://dx.doi.org/10.1016/j.jocn.2012.07.022 | DOI Listing |
Alzheimers Dement
December 2024
Neurocognitive Unit, Division of Neurology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Background: Alzheimer's disease(AD) raises global concern with its impact on daily living. Anti-amyloid monoclonal antibodies (mAb) serving as specific treatments used in mild cognitive impairment(MCI) and mild dementia due to AD. Severe cerebral small vessel disease(SVD) lesions such as microbleeds and white matter hyperintensities are listed as exclusions according to the recommendation for mAb treatment.
View Article and Find Full Text PDFBackground: Microhemorrhages and superficial siderosis (SS) have been reported in patients with mild cognitive impairment (MCI) and dementia, especially in the context of Alzheimer's disease (AD) and cerebrovascular disease. Cerebral amyloid angiopathy and small vessel disease (SVD) have both been implicated in microhemorrhages and SS but their prevalence in those with MCI and dementia and their relationship to SVD is unknown.
Method: We conducted a retrospective chart review of patients with MCI or dementia that had undergone MRI scans from 2014 To 2023.
Background: Socioeconomic factors have an impact on long-term neurovascular health. Education attainment (EA) is a socioeconomic factor which may be related to vascular risk factors and brain health. We investigated the relation of EA and cerebral small vessel disease (CSVD) in community dwelling participants free of stroke and dementia.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Knight Alzheimer Disease Research Center, St. Louis, MO, USA.
Background: Amyloid-related Imaging Abnormalities (ARIA) are side effects of beta-amyloid plaque-lowering monoclonal antibody drugs (APLmAbs). Understanding of ARIA mechanisms, risks, nature, evolution and optimal approaches to mitigation and management remains incomplete. Sporadic Alzheimer's Disease (AD) trials support ARIA risk factors including higher APLmAb doses/exposures, ApoE4-carrier status, and presence/severity of microhemorrhages (MCH)/superficial siderosis.
View Article and Find Full Text PDFBackground: ALZ-801/valiltramiprosate, an oral small molecule inhibitor of amyloid oligomer formation, is being evaluated in a Phase 3 trial in APOE4/4 Early AD subjects (APOLLOE4). Topline results are expected in 3Q 2024. APOE4 is a major risk factor for Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) with a gene-dose effect.
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