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| http://dx.doi.org/10.1016/j.bpj.2013.03.050 | DOI Listing |
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Kinesin-5/Cut7 C-terminal tail phosphorylation is essential for microtubule sliding force and bipolar mitotic spindle assembly.
Curr Biol
October 2024
Department of Physics, University of Colorado Boulder, Colorado Avenue, Boulder, CO 80309, USA; Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Colorado Avenue, Boulder, CO 80309, USA. Electronic address:
Kinesin-5 motors play an essential role during mitotic spindle assembly in many organisms: they crosslink antiparallel spindle microtubules, step toward plus ends, and slide the microtubules apart. This activity separates the spindle poles and chromosomes. Kinesin-5s are not only plus-end-directed but can walk or be carried toward MT minus ends, where they show enhanced localization.
View Article and Find Full Text PDFSuccessive Kinesin-5 Microtubule Crosslinking and Sliding Promote Fast, Irreversible Formation of a Stereotyped Bipolar Spindle.
Curr Biol
November 2019
Department of Biology, McGill University, 1205 Avenue Doctor Penfield, Montreal, QC H3A 1B1, Canada; Integrated Quantitative Biology Initiative, McGill University, 1205 Avenue Doctor Penfield, Montreal, QC H3A 1B1, Canada. Electronic address:
Separation of duplicated spindle poles is the first step in forming the mitotic spindle. Kinesin-5 crosslinks and slides anti-parallel microtubules (MTs), but it is unclear how these two activities contribute to the first steps in spindle formation. In this study, we report that in monopolar spindles, the duplicated spindle poles snap apart in a fast and irreversible step that produces a nascent bipolar spindle.
View Article and Find Full Text PDFKinesins in MAPK cascade: How kinesin motors are involved in the MAPK pathway?
Gene
February 2019
The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:
Kinesins are essential for the transport and positioning of several biomolecules through moving along the microtubule in eukaryotic cells. Up to now, there are 14 kinesin family proteins known. The MAPK pathway which is composed of multiple proteins constituting a complex cascade also plays important roles in cell proliferation, differentiation and apoptosis in eukaryotic cells.
View Article and Find Full Text PDFGold nanocrystal-mediated sliding of doublet DNA origami filaments.
Nat Commun
April 2018
Max Planck Institute for Intelligent Systems, Heisenbergstrasse 3, D-70569, Stuttgart, Germany.
Sliding is one of the fundamental mechanical movements in machinery. In macroscopic systems, double-rack pinion machines employ gears to slide two linear tracks along opposite directions. In microscopic systems, kinesin-5 proteins crosslink and slide apart antiparallel microtubules, promoting spindle bipolarity and elongation during mitosis.
View Article and Find Full Text PDFExploiting the kinesin-1 molecular motor to generate a virus membrane penetration site.
Nat Commun
May 2017
Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, 3043 BSRB, Ann Arbor, Michigan 48109, USA.
Viruses exploit cellular machineries to penetrate a host membrane and cause infection, a process that remains enigmatic for non-enveloped viruses. Here we probe how the non-enveloped polyomavirus SV40 penetrates the endoplasmic reticulum (ER) membrane to reach the cytosol, a crucial infection step. We find that the microtubule-based motor kinesin-1 is recruited to the ER membrane by binding to the transmembrane J-protein B14.
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