We argue that brains generate predictions only within the constraints of the action repertoire. This makes the computational complexity tractable and fosters a step-by-step parallel development of sensory and motor systems. Hence, it is more of a benefit than a literal constraint and may serve as a universal normative principle to understand sensorimotor coupling and interactions with the world.
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http://dx.doi.org/10.1017/S0140525X12002294 | DOI Listing |
J Neuroeng Rehabil
December 2024
Laboratory for Neuro- & Psychophysiology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Background: The loss of finger control in individuals with neuromuscular disorders significantly impacts their quality of life. Electroencephalography (EEG)-based brain-computer interfaces that actuate neuroprostheses directly via decoded motor intentions can help restore lost finger mobility. However, the extent to which finger movements exhibit distinct and decodable EEG correlates remains unresolved.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Key Laboratory of Animal Breeding and Healthy Livestock Farming, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China.
The CRISPR-Cas system functions as an adaptive immune mechanism in archaea and bacteria, providing defense against the invasion of foreign nucleic acids. Most CRISPR-Cas systems are classified into class 1 or class 2, with further subdivision into several subtypes. The primary distinction between class 1 and class 2 systems lies in the assembly of their effector modules.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Institute of Pharmacy and Molecular Biotechnology (IPMB), Faculty of Engineering Sciences, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg 69120, Germany.
Light-controlled transcriptional activation is a commonly used optogenetic strategy that allows researchers to regulate gene expression with high spatiotemporal precision. The vast majority of existing tools are, however, limited to light-triggered induction of gene expression. Here, we inverted this mode of action and created optogenetic systems capable of efficiently terminating transcriptional activation in response to blue light.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Chemistry, University of Pavia, viale Taramelli, 10, Pavia, 27100, Italy.
Compounds targeting non-canonical secondary structures of nucleic acids, known as G-quadruplexes, are highly cytotoxic, both for cancer and healthy cells, because of their action mechanism's lack of appropriate selectivity. The targeted delivery of cytotoxic molecules to cancer cells is a valuable strategy to expand the repertoire of potential drugs, especially for cancer types for which new therapeutic tools are urgently needed, like glioblastoma. In this work, we conjugated a cyclic arginyl-glycyl-aspartic acid peptide to a naphthalene diimide, previously described as a highly performing stabilizing ligand for DNA G-quadruplexes, to specifically target glioma cells overexpressing RGD-binding integrin receptors.
View Article and Find Full Text PDFJ Mol Biol
November 2024
Faculty of Science, University of South Bohemia, Ceske Budejovice 37005, Czech Republic; Institute of Entomology, Biology Center of the Czech Academy of Sciences, Ceske Budejovice 37005, Czech Republic. Electronic address:
Transcription factors of the bHLH-PAS family play vital roles in animal development, physiology, and disease. Two members of the family require binding of low-molecular weight ligands for their activity: the vertebrate aryl hydrocarbon receptor (AHR) and the insect juvenile hormone receptor (JHR). In the fly Drosophila melanogaster, the paralogous proteins GCE and MET constitute the ligand-binding component of JHR complexes.
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