AI Article Synopsis

  • The text reviews the concepts of eubiosis (healthy microbiota) and dysbiosis (imbalanced microbiota) in the gastrointestinal tract, highlighting their significance under both normal and disease states.
  • Current debates surrounding these concepts, including classifications of colonic dysbiosis and common misconceptions, are addressed along with the authors' perspectives.
  • Diagnostic methods for identifying dysbiosis, their effectiveness, associated diseases, and strategies for correction are also outlined.

Article Abstract

Current data on eubiosis and dysbiosis of gastrointestinal tract are discussed along with the role of its microflora in human body under normal and pathological conditions. Certain debatable problems are discussed. Classification of colonic dysbiosis is presented with reference to its stages, functions of normal flora, "myths" related to the science of eubiosis and dysbiosis, the authors views of the problem. Diagnostic methods and their informative value are described. The main diseases and syndromes associated with intestinal dysbiosis are discussed. In conjunction with approaches to its correction.

Download full-text PDF

Source

Publication Analysis

Top Keywords

dysbiosis gastrointestinal
8
gastrointestinal tract
8
eubiosis dysbiosis
8
[eubiosis dysbiosis
4
tract myths
4
myths reality]
4
reality] current
4
current data
4
data eubiosis
4
dysbiosis
4

Similar Publications

Background And Aims: Oral microbiota may contribute to the development of upper gastrointestinal (UGI) disorders. We aimed to study the association between the microbiome of saliva, subgingival and buccal mucosa, and UGI disorders, particularly precancerous lesions. We also aimed to determine which oral site might serve as the most effective biomarker for UGI disorders.

View Article and Find Full Text PDF

Increasing evidence suggests that dysbiosis of gut microbiota exacerbates chronic kidney disease (CKD) progression. Curcumin (CUR) has been reported to alleviate renal fibrosis in animal models of CKD. However, the relationship between CUR and gut microbiome in CKD remains unclear.

View Article and Find Full Text PDF

Public Health.

Alzheimers Dement

December 2024

Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Background: Current literature focuses on the association between gut dysbiosis and the aggregation of Aβ, the development of tau protein, as well as neuroinflammation and oxidative stress associated with AD. Since the brain and gut are connected (gut-brain axis), gut microbiota and their metabolites may influence AD progression, or vice versa, if AD pathogenesis impacts the microbiome. Observational studies have shown an altered taxonomic composition of gut microbiota in AD patients compared to cognitively normal (CN) controls.

View Article and Find Full Text PDF

Biomarkers.

Alzheimers Dement

December 2024

Memory Resources and Research Center, CHRU Gui de Chauliac, Montpellier, France.

Background: Microbiota is modulated by normal aging, but also by Alzheimer's disease (AD) risk factors as poor diet or alteration of sleep patterns. Patients with AD exhibit a dysbiosis characterized by changes in the relative proportions of specific bacterial phyla. Eventually, fecal microbiota transplants (FMT) can improve cognitive deficits and reduce amyloid-ß deposition, at least in mouse models of AD.

View Article and Find Full Text PDF

Developing Topics.

Alzheimers Dement

December 2024

University of Puerto Rico, Medical Sciences Campus, School of Medicine, San Juan, PR, USA.

Background: Alzheimer's disease (AD) comprise over 70% of dementia cases in the United States (US), characterized by progressive neurodegenerative symptoms. In the US and Puerto Rico (PR), AD is the sixth and fourth leading cause of death, respectively. The Gut-Brain Axis is a bidirectional communication mechanism between the central nervous system and microbes that reside in the gastrointestinal tract.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!