Current data on eubiosis and dysbiosis of gastrointestinal tract are discussed along with the role of its microflora in human body under normal and pathological conditions. Certain debatable problems are discussed. Classification of colonic dysbiosis is presented with reference to its stages, functions of normal flora, "myths" related to the science of eubiosis and dysbiosis, the authors views of the problem. Diagnostic methods and their informative value are described. The main diseases and syndromes associated with intestinal dysbiosis are discussed. In conjunction with approaches to its correction.
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Am J Gastroenterol
December 2024
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden.
Background And Aims: Oral microbiota may contribute to the development of upper gastrointestinal (UGI) disorders. We aimed to study the association between the microbiome of saliva, subgingival and buccal mucosa, and UGI disorders, particularly precancerous lesions. We also aimed to determine which oral site might serve as the most effective biomarker for UGI disorders.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Kidney Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaan'xi, China.
Increasing evidence suggests that dysbiosis of gut microbiota exacerbates chronic kidney disease (CKD) progression. Curcumin (CUR) has been reported to alleviate renal fibrosis in animal models of CKD. However, the relationship between CUR and gut microbiome in CKD remains unclear.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Background: Current literature focuses on the association between gut dysbiosis and the aggregation of Aβ, the development of tau protein, as well as neuroinflammation and oxidative stress associated with AD. Since the brain and gut are connected (gut-brain axis), gut microbiota and their metabolites may influence AD progression, or vice versa, if AD pathogenesis impacts the microbiome. Observational studies have shown an altered taxonomic composition of gut microbiota in AD patients compared to cognitively normal (CN) controls.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Memory Resources and Research Center, CHRU Gui de Chauliac, Montpellier, France.
Background: Microbiota is modulated by normal aging, but also by Alzheimer's disease (AD) risk factors as poor diet or alteration of sleep patterns. Patients with AD exhibit a dysbiosis characterized by changes in the relative proportions of specific bacterial phyla. Eventually, fecal microbiota transplants (FMT) can improve cognitive deficits and reduce amyloid-ß deposition, at least in mouse models of AD.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Puerto Rico, Medical Sciences Campus, School of Medicine, San Juan, PR, USA.
Background: Alzheimer's disease (AD) comprise over 70% of dementia cases in the United States (US), characterized by progressive neurodegenerative symptoms. In the US and Puerto Rico (PR), AD is the sixth and fourth leading cause of death, respectively. The Gut-Brain Axis is a bidirectional communication mechanism between the central nervous system and microbes that reside in the gastrointestinal tract.
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