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Skin-associated shares cobamides.
mSphere
December 2024
Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Unlabelled: The underlying interactions that occur to maintain skin microbiome composition, function, and overall skin health are largely unknown. Often, these types of interactions are mediated by microbial metabolites. Cobamides, the vitamin B family of cofactors, are essential for metabolism in many bacteria but are only synthesized by a fraction of prokaryotes, including certain skin-associated species.
View Article and Find Full Text PDFCutaneous protothecosis: a new case and review of Brazilian patients.
Dermatol Online J
October 2024
Institute of Dermatology Professor Rubem David Azulay, Rio de Janeiro, Brazil.
Protothecosis is a rare but emerging infectious disease, caused by algae from the genus Prototheca. It presents predominantly as cutaneous lesions and poses a diagnostic challenge owing to its diverse clinical presentation. Typically, it occurs in exposed areas of the skin, associated with trauma.
View Article and Find Full Text PDFBackground: Skin atrophy and fragility associated with Dermatoporosis result from chronic extracellular matrix (ECM) degradation. A current marketed product, ReFORM & RePAIR COMPLEX with TriHex Technology® (R&R, Alastin Skincare, Inc.), contains actives that aid in recycling the ECM with new matrix components that have been found to be deficient in patients with DP.
View Article and Find Full Text PDFFibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice.
Matrix Biol
February 2025
Tsukuba Advanced Research Alliance (TARA), Life Science Center for Survival Dynamics, University of Tsukuba, Japan. Electronic address:
Fibrillin-1, an extracellular matrix (ECM) protein encoded by the FBN1 gene, serves as a microfibril scaffold crucial for elastic fiber formation and homeostasis in pliable tissue such as the skin. Aside from causing Marfan syndrome, some mutations in FBN1 result in scleroderma, marked by hardened and thicker skin which limits joint mobility. Here, we describe a tight skin phenotype in the Fbn1 mice carrying a corresponding variant of FBN1 in the hybrid1 domain that was identified in a patient with familial aortic dissection.
View Article and Find Full Text PDFLarge-scale investigation for antimicrobial activity reveals novel defensive species across the healthy skin microbiome.
bioRxiv
November 2024
Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Article Synopsis
- The human skin microbiome acts as a protective barrier against pathogens by producing antimicrobial substances, making it a valuable resource for discovering new natural products.
- Researchers introduced the EPithelial Isolate Collection (EPIC), which comprises 980 diverse bacterial strains from human skin across eight body sites, including many rare strains with unique biosynthetic gene clusters (BGCs).
- Through extensive testing, they found that this microbiome exhibits strong antifungal properties, with certain body sites showing higher potential for discovering new bioactive compounds, leading to advancements in antimicrobial drug development and microbiome research.
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