AI Article Synopsis
- Researchers developed gold nanoparticle agents that can absorb X-rays by modifying a cisplatin compound with polyacrylate.
- These agents are effective against cancer cells, demonstrating both chemotherapy effects and enhanced radiation treatment due to secondary electron emission.
- This innovative approach holds promise for increasing the effectiveness of combined chemo-radiation therapies in cancer treatment.
Article Abstract
We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957245 | PMC |
| http://dx.doi.org/10.1039/c3nr00333g | DOI Listing |
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