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New coumarin derivatives as carbonic anhydrase inhibitors. | LitMetric
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New coumarin derivatives as carbonic anhydrase inhibitors.

Mert Olgun Karataş Bülent Alici Umit Cakir Engin Cetinkaya Dudu Demir Adem Ergün Nahit Gençer Oktay Arslan

Artif Cells Nanomed Biotechnol

Inonu University, Faculty of Arts and Sciences, Department of Chemistry 44280 , Malatya , Turkey.

Published: June 2014

In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 μM for hCA I and 88 μM for hCA II) performed higher inhibitory activity than others.

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http://dx.doi.org/10.3109/21691401.2013.794352DOI Listing

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