[Influence of magnesium supplementation on insulin receptor affinity in erythrocytes of type 2 diabetes rats].

Objective: To observe the influence of oral magnesium supplementation on insulin receptor affinity in erythrocytes of type 2 diabetes rats.

Method: diabetes rats were induced by high-fat-diet and intraperitoneal injection of streptozocin, and divided into 4 groups. Magnesium was supplemented in high-fat-diet at the dose of 2000, 1000, 200 and 0 mg/kg,respectively. Normal control rats were fed with ordinary diet. Rats were killed after four weeks. Erythrocytes insulin receptor number, combination constants, combined capacity, fasting insulin level and fasting glucose levels were measured, and insulin resistance index and insulin sensitivity index were calculated.

Results: High affinity insulin receptor combination constant, combined capacity and receptor number in high dosage group were (1.24 +/- 0.47) x 10(9) L/mol, (1.26 +/- 0.53) x 10(14)/L and 80.23 +/- 0.47 respectively, significantly higher than diabetes control group. Insulin resistance index decreased and insulin sensitivity index increased in high dosage group than diabetes control.

Conclusion: Magnesium supplementation could improve erythrocyte insulin receptor affinity and improve insulin resistance in type 2 diabetic rats.