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| http://dx.doi.org/10.1038/jid.2013.218 | DOI Listing |
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Spitz melanocytic neoplasms with MLPH::ALK fusions: Report of two cases with previously unreported features and literature review.
J Cutan Pathol
June 2024
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Article Synopsis
- - ALK-fused Spitz melanocytic neoplasms are a unique type of skin tumor with distinct growth patterns and histological characteristics, often appearing as raised, polyp-like masses.
- - Various gene fusions, particularly with ALK involving partners like TPM3 and DCTN1, are identified in these tumors, while MLPH is a rare but significant fusion partner influencing melanin transport.
- - This report adds two new cases, including one of Spitz melanoma, enhancing the existing literature on ALK-fused Spitz melanocytic neoplasms and their clinical and molecular features.
Circ-FNDC3B Functions as an Oncogenic Factor in Esophageal Squamous Cell Carcinoma via Upregulating MYO5A by Absorbing miR-136-5p and miR-370-3p.
Biochem Genet
October 2023
Department of Cardiothoracic Surgery, Zigong First People's Hospital, No.42nd, ShangYiHao Branch 1st, Zi Liu Jing District, Zigong City, 643000, Sichuan Province, China.
Circular RNAs (circRNAs) are a class of key regulators in cancers via regulating gene levels by acting as sponges of miRNAs. This study was devoted to explore the functional mechanism of circRNA fibronectin type III domain-containing protein 3B (circ-FNDC3B) in esophageal squamous cell carcinoma (ESCC). RNA levels were examined via reverse transcription-quantitative polymerase chain reaction assay.
View Article and Find Full Text PDFProlonged ethanol exposure modulates constitutive internalization and recycling of 5-HT1A receptors.
J Neurochem
February 2022
Department of Physiology & Pharmacology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Alcohol exposure alters the signaling of the serotoninergic system, which is involved in alcohol consumption, reward, and dependence. In particular, dysregulation of serotonin receptor type 1A (5-HT1AR) is associated with alcohol intake and withdrawal-induced anxiety-like behavior in rodents. However, how ethanol regulates 5-HT1AR activity and cell surface availability remains elusive.
View Article and Find Full Text PDFCentral GLP-1 contributes to improved cognitive function and brain glucose uptake after duodenum-jejunum bypass on obese and diabetic rats.
Am J Physiol Endocrinol Metab
September 2021
Department of Colorectal Surgery, General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
The improvement of cognitive function following bariatric surgery has been highlighted, yet its underlying mechanisms remain elusive. Finding the improved brain glucose uptake of patients after Roux-en-Y gastric bypass (RYGB), duodenum-jejunum bypass (DJB), and sham surgery (Sham) were performed on obese and diabetic Wistar rats, and intracerebroventricular (ICV) injection of glucagon-like peptide-1 (GLP-1) analog liraglutide (Lira), antagonist exendin-(9-39) (Exe-9), and the viral-mediated GLP-1 receptor () knockdown (KD) were applied on both groups to elucidate the role of GLP-1 in mediating cognitive function and brain glucose uptake assessed with the Morris water maze (MWM) and positron emission tomography (PET). Insulin and GLP-1 in serum and cerebral spinal fluid (CSF) were measured, and the expression of glucose uptake-related proteins including glucose transporter 1 (GLUT-1), GLUT-4, phospho-Akt substrate of 160kDa (pAS160), AS160, Rab10, Myosin-Va as well as the marker in the brain were examined.
View Article and Find Full Text PDFAssociation of microtubules and axonal RNA transferred from myelinating Schwann cells in rat sciatic nerve.
PLoS One
August 2020
Departamento de Proteínas y Ácidos Nucleicos, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
Transference of RNAs and ribosomes from Schwann cell-to-axon was demonstrated in normal and regenerating peripheral nerves. Previously, we have shown that RNAs transfer is dependent on F-actin cytoskeleton and Myosin Va. Here, we explored the contribution of microtubules to newly synthesized RNAs transport from Schwann cell nuclei up to nodal microvilli in sciatic nerves.
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