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| http://dx.doi.org/10.1038/ejhg.2013.65 | DOI Listing |
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Computational insights into the redox properties and electronic structures of [Tc=O] complexes: Implications for Tc-radiopharmaceuticals.
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"VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, 11001, Belgrade, Serbia.
Technetium-99m plays a pivotal role in nuclear medicine, offering unique IMAGING capabilities due to its favorable physical and chemical properties. This study investigates the redox behavior and electronic structures of three representative Tc(V) oxo complexes, [TcO(HMPAO)], [TcO(Bicisate)], and [TcO(DMSA)], using computational techniques. Employing relativistic density functional theory with the Zero-Order Regular Approximation (ZORA), we analyze singlet-triplet energy gaps, Gibbs free energy changes, and redox potentials in neutral and acidic environments.
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Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
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