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High Expression of SMN circ4-2b-3 in SMA I Children Treated with Nusinersen is Associated with Improved Motor Outcomes.
Mol Neurobiol
November 2024
Pediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Spinal muscular atrophy (SMA) is a neuromuscular disorder resulting in the loss of α-motor neurons. Nusinersen is an antisense oligonucleotide administered intrathecally to SMA patients that corrects the splicing defect of SMN2. Not all SMA patients respond equally to the therapy and work is in progress to identify biomarkers that may help stratify to SMA patients.
View Article and Find Full Text PDFHeart Rate Recovery Index and Improved Diastolic Dyssynchrony in Fusion Pacing Cardiac Resynchronization Therapy.
J Clin Med
October 2024
Department of Cardiology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Restoring electrical synchrony with cardiac resynchronization therapy (CRT) reverses the heart failure phenotype developed by left-ventricular (LV) dyssynchrony. This study aimed to identify new predictors of response to LV-only fusion pacing CRT. A select group of patients with CRT-P indications received a right atrium (RA)/LV DDD pacing system.
View Article and Find Full Text PDFLeft Atrium Reverse Remodeling in Fusion CRT Pacing: Implications in Cardiac Resynchronization Response and Atrial Fibrillation Incidence.
J Clin Med
August 2024
Department of Cardiology, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
: When compared to biventricular pacing, fusion CRT pacing was linked to a decreased incidence of atrial fibrillation (AF). There is a gap in the knowledge regarding exclusive fusion CRT without interference with RV pacing, and all the current data are based on populations of patients with intermittent fusion pacing. : To assess left atrium remodeling and AF incidence in a real-life population of permanent fusion CRT-P.
View Article and Find Full Text PDFA predictive model of super response to cardiac resynchronization therapy in short-term period.
J Interv Card Electrophysiol
November 2024
Department of Surgical Arrhythmology and Cardiac Pacing, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kievskaya Street, 111a, Tomsk, Russian Federation.
Background: The left bundle branch block, nonischemic heart failure (HF) and female gender are the most powerful predictors of a super response to cardiac resynchronization therapy (CRT). It is important to identify super responders who can derive most benefits from CRT. We aimed to establish a predicting model that could be used for prognosis of a super response to CRT in short-term period.
View Article and Find Full Text PDFPredictors for Super-Responders in Cardiac Resynchronization Therapy.
Am J Ther
January 2024
Department of Cardiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Background: Prediction of cardiac resynchronization therapy (CRT) response, particularly a super-response, is of great importance.
Study Question: The aim of our study was to assess the predictors for super-responders in CRT.
Study Design: We conducted a retrospective, observational study, which finally included 622 patients with heart failure treated with CRT between January 2008 and May 2020 who had a minimal follow-up of 6 months after CRT.
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