AI Article Synopsis
- Diabetic nephropathy involves multiple signaling issues and can worsen with aggressive glucose-lowering treatments that may lead to hypoglycemic events.
- Curcumin, an active compound in turmeric, is recognized for its long-standing use in treating various ailments due to its antioxidant and anti-inflammatory effects.
- The text emphasizes curcumin's protective role against kidney damage in diabetes and discusses efforts to enhance its effectiveness in the body.
Article Abstract
Diabetic nephropathy is characterized by a plethora of signaling abnormalities. Recent trials have suggested that intensive glucose-lowering treatment leads to hypoglycemic events, which can be dangerous. Curcumin is the active ingredient of turmeric, which has been widely used in many countries for centuries to treat numerous diseases. The preventive and therapeutic properties of curcumin are associated with its antioxidant and anti-inflammatory properties. Here, we highlight the renoprotective role of curcumin in diabetes mellitus (DM) with an emphasis on the molecular basis of this effect. We also briefly discuss the numerous approaches that have been undertaken to improve the pharmacokinetics of curcumin.
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| http://dx.doi.org/10.1016/j.drudis.2013.04.009 | DOI Listing |
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