Gatifloxacin is a fourth generation fluroquinolone antibiotic that has been prescribed for systemic use. However, the drug which was developed by Kyorin (Japan) was linked to toxic reactions and death and was banned in the United States and Canada for use as an oral dosage form. It continues to be used as a topical application for ophthalmic conditions as the systemic toxicity seen when taking the drug orally has not been observed with ophthalmic use. The available data indicate that ocular use of gatifloxacin is safe, and effective against a broad spectrum of bacteria, including intracellular bacteria and anaerobes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619660 | PMC |
| http://dx.doi.org/10.4137/OED.S7383 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Thelaziasis in an urban woman in Beijing: a case report and literature review.
BMC Ophthalmol
November 2024
Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, No 49 North Garden Road, Haidian District, Beijing, 100191, China.
Article Synopsis
- Thelaziasis, caused by the parasitic worm Thelazia callipaeda, leads to various eye-related symptoms, potentially resulting in serious conditions like conjunctivitis or blindness, particularly in areas with contact to domestic animals.
- A 41-year-old woman experienced persistent eye discomfort attributed to Thelazia callipaeda, despite initial treatments, but underwent successful removal of the worms from her eye.
- The case emphasizes the need for healthcare professionals to consider parasitic infections in diagnosing eye issues, even in urban settings, and suggests that regional studies on the prevalence of human thelaziasis in China are necessary.
[A case of Nocardia cyriacigeorgica endophthalmitis after intraocular surgery].
Zhonghua Yan Ke Za Zhi
November 2024
Yantai YEDA Hospital (Yantai Eye Hospital), Yantai 264000, China.
A 64-year-old male farmer diagnosed as lens subluxation, cataract, secondary glaucoma, iris tear, old trauma and lower eyelid ectropion underwent cataract extraction, intraocular lens suspension fixation and coreoplasty. Mild intermittent ophthalmic pain occurred from half a month after surgery, and suppurative endophthalmitis was diagnosed 23 days after surgery. Vitrectomy was performed.
View Article and Find Full Text PDFPharmacokinetic Analysis of Gatifloxacin and Dexamethasone in Rabbit Ocular Biofluid Using a Sensitive and Selective LC-MS/MS Method.
J Mass Spectrom
October 2024
Pharmaceutics and Pharmacokinetic Division, CSIR-Central Drug Research Institute, Lucknow, India.
Article Synopsis
- Bacterial keratitis is a serious eye infection that can lead to corneal inflammation and potentially blindness, but can be treated with topical fluoroquinolones and corticosteroids like Gatifloxacin and Dexamethasone.
- A new bioanalytical method using tandem mass spectrometry (LC-MS/MS) has been developed to simultaneously measure Gatifloxacin and Dexamethasone, achieving separation in under 5 minutes with high accuracy.
- The method was validated according to USFDA guidelines and applied successfully in a study analyzing these drugs in rabbit tear fluid after topical application, demonstrating its effectiveness for pharmacokinetic analysis.
A Case of Parinaud Oculoglandular Syndrome in Which DNA Was Detected in the Cornea and Conjunctiva by Polymerase Chain Reaction.
Medicina (Kaunas)
August 2024
Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Nagasaki, Japan.
Article Synopsis
- Parinaud oculoglandular syndrome (POS) is a condition characterized by unilateral eye inflammation and lymphadenopathy, often linked to infections like cat-scratch disease.
- A 29-year-old man developed POS after adopting a stray cat, experiencing symptoms like fever and eye discharge; tests confirmed the presence of the disease-causing DNA.
- After two weeks of oral medication and two months of topical treatment, the patient's eye condition improved significantly, highlighting the value of PCR testing in diagnosing ocular infections related to POS.
Elucidating acceptance and clinical indications to support the rational design of drug-eluting contact lenses.
Int J Pharm
November 2024
School of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets, Nantong University, Nantong 226001, China. Electronic address:
The advent of drug-eluting contact lenses (DECLs) has opened up new avenues for the treatment of eye diseases. DECLs is expected to partially overcome the shortcomings of eye drops due to single-dose packaging, accurate dosing, prolonged drug elution behavior, and simplified dosing procedures. Currently, a significant proportion of the DECLs design effort has been directed towards enhancing the compatibility of contact lenses with drugs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!