AI Article Synopsis
- PGC-1α is a key regulator of metabolic changes in skeletal muscle, particularly in response to exercise.
- It promotes the expression of LDH B while reducing LDH A and its regulator, which helps maintain balanced lactate levels in the blood.
- This coordination of the LDH complex by PGC-1α enhances muscle adaptations from training, leading to improved exercise performance and better metabolic health.
Article Abstract
The peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) controls metabolic adaptations. We now show that PGC-1α in skeletal muscle drives the expression of lactate dehydrogenase (LDH) B in an estrogen-related receptor-α-dependent manner. Concomitantly, PGC-1α reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene. PGC-1α thereby coordinately alters the composition of the LDH complex and prevents the increase in blood lactate during exercise. Our results show how PGC-1α actively coordinates lactate homeostasis and provide a unique molecular explanation for PGC-1α-mediated muscle adaptations to training that ultimately enhance exercise performance and improve metabolic health.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666691 | PMC |
| http://dx.doi.org/10.1073/pnas.1212976110 | DOI Listing |
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