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Norepinephrine and serotonin increase the vasoconstrictor response of the perfused rat tail artery to changes in cytosolic Ca2+. | LitMetric
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Norepinephrine and serotonin increase the vasoconstrictor response of the perfused rat tail artery to changes in cytosolic Ca2+.

N Thorin-Trescases L Oster J Atkinson C Capdeville

Eur J Pharmacol

Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Nancy, France.

Published: April 1990

Vasoconstriction and changes in cytosolic free Ca2+ concentrations (fura 2 with dual wavelength excitation) were measured simultaneously in the perfused tail artery of the rat. Vasoconstrictors (norepinephrine and 5-HT) appear to modulate contraction not only by changing the cytosolic free Ca2+ concentration but also by modifying the sensitivity of the contractile proteins to Ca2+.

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http://dx.doi.org/10.1016/0014-2999(90)90191-8DOI Listing

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