AI Article Synopsis
- This study focuses on creating and assessing the antimicrobial properties of hydrazones derived from specific chemical compounds.
- The researchers characterized the new compounds using various spectroscopic techniques and tested their effectiveness against different types of bacteria and one fungal strain.
- Notably, three hydrazones showed significant potential as antimicrobial agents against key bacteria like E. coli and S. aureus, and their effects on tumor and fibroblast cells were also evaluated.
Article Abstract
In this work we reported the synthesis and evaluation of in vitro antimicrobial activities of hydrazones 6 obtained from 3-oxido-1H-imidazole-4-carbohydrazides 4. All new compounds were characterized by spectroscopic methods. Hydrazones 6 were tested for their in vitro antimicrobial activity against four Gram-positive and four Gram-negative strains of bacteria as well as one fungal species. Three of the tested compounds appeared to be promising agents against reference strains of Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis. They were also tested against twelve clinical isolates of S. aureus and their cytotoxic effect on murine fibroblasts and HeLa human tumor cell line was determined.
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| http://dx.doi.org/10.1016/j.ejmech.2013.04.023 | DOI Listing |
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