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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861049 | PMC |
| http://dx.doi.org/10.1016/j.ihj.2013.03.007 | DOI Listing |
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The activity of a herbal medicinal product of Phyllanthus niruri and Silybum marianum powdered extracts (Heptex®) in patients with apparent risk factors for nonalcoholic steatohepatitis: a phase II, multicentered, randomized, double-blind, placebo-controlled clinical trial.
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School of Pharmaceutical Sciences, University Sains Malaysia, Gelugor, Malaysia.
Background: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) characterized by damage and inflammation of hepatocytes. Some medicinal plants have shown antioxidant and anti-inflammatory effects on liver cells. We aimed to investigate the hepatoprotective effect of Heptex® capsules containing 200 mg of Dukung Anak (a powdered extract from aerial parts of Phyllanthus niruri) and 100 mg of Milk Thistle (a powdered extract from fruits of Silybum marianum) in patients with an apparent risk factor for NASH.
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Chengfa Urban Service Technology (Henan) Co., Ltd, Zhengzhou, 450002, People's Republic of China.
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Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang Province, China.
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